Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3122805..3124579 | Replicon | chromosome |
| Accession | NZ_CP069076 | ||
| Organism | Mycobacterium tuberculosis strain N0031 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | JN136_RS14880 | Protein ID | WP_003414409.1 |
| Coordinates | 3122805..3123689 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | JN136_RS14885 | Protein ID | WP_003414414.1 |
| Coordinates | 3123692..3124579 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN136_RS14860 | 3118060..3118434 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| JN136_RS14865 | 3118431..3120869 | - | 2439 | WP_003900580.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| JN136_RS14870 | 3120866..3121654 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| JN136_RS14875 | 3121988..3122533 | - | 546 | WP_014584866.1 | DUF1802 family protein | - |
| JN136_RS14880 | 3122805..3123689 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JN136_RS14885 | 3123692..3124579 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JN136_RS14890 | 3124884..3125429 | - | 546 | WP_014584866.1 | DUF1802 family protein | - |
| JN136_RS14895 | 3125426..3125695 | - | 270 | WP_003912856.1 | DUF2277 family protein | - |
| JN136_RS14900 | 3125716..3126108 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN136_RS14905 | 3126105..3126320 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN136_RS14910 | 3126367..3127116 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| JN136_RS14915 | 3127195..3128277 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T189754 WP_003414409.1 NZ_CP069076:c3123689-3122805 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T189754 NZ_CP090974:1737644-1738036 [Shewanella sp. OMA3-2]
ATGGATATCATTTGCTTTCCATTCGAGCGTGTTATCGAAATCAATACTTTTATTTTAGAAACTGAACCTGGCATGAAAGG
GCAGGTAGATGTTTCAAAATTACAAGGTGCATTAGGGCGTATTGATAATGCAATTGTGTACGATGGTTTAGATGATATTT
TTGAAATTGCTGCAAAATATACTGCAAGTATTGCTATTGCTCATTCACTACCAGATGCGAATAAACGCACAGGATTGATT
GTTGCACTTGAGTATTTGTCATTAAATGATTTTGAACTTACAAGCGACAACACACTATTAGCCGATGCAGTAAGAGATTT
AGTTCTTGGTGTGATTGGTGAAAGTGATTTTGCTGACATATTGTATGCCCAATATGCGCAAGAAAATCAGTAG
ATGGATATCATTTGCTTTCCATTCGAGCGTGTTATCGAAATCAATACTTTTATTTTAGAAACTGAACCTGGCATGAAAGG
GCAGGTAGATGTTTCAAAATTACAAGGTGCATTAGGGCGTATTGATAATGCAATTGTGTACGATGGTTTAGATGATATTT
TTGAAATTGCTGCAAAATATACTGCAAGTATTGCTATTGCTCATTCACTACCAGATGCGAATAAACGCACAGGATTGATT
GTTGCACTTGAGTATTTGTCATTAAATGATTTTGAACTTACAAGCGACAACACACTATTAGCCGATGCAGTAAGAGATTT
AGTTCTTGGTGTGATTGGTGAAAGTGATTTTGCTGACATATTGTATGCCCAATATGCGCAAGAAAATCAGTAG
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT189754 WP_003414414.1 NZ_CP069076:c3124579-3123692 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT189754 NZ_CP090974:1737474-1737644 [Shewanella sp. OMA3-2]
ATGAACAAGAAAGTTGAGGCATATGGTGTTAATGCAATTATTCGTCCGAAAATAACAGCCACTAAAGAGCTTGATTTGTC
TGGAATTTATGGACAACAAATTGTTAAGTCTGAGACAAAGCTAGCTTTGAGAACACACCGTAAAACGTTCGAGAAATTGG
CTGATATGTAA
ATGAACAAGAAAGTTGAGGCATATGGTGTTAATGCAATTATTCGTCCGAAAATAACAGCCACTAAAGAGCTTGATTTGTC
TGGAATTTATGGACAACAAATTGTTAAGTCTGAGACAAAGCTAGCTTTGAGAACACACCGTAAAACGTTCGAGAAATTGG
CTGATATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|