Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2856044..2856675 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag JN136_RS13420 Protein ID WP_003413174.1
Coordinates 2856298..2856675 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag JN136_RS13415 Protein ID WP_003413167.1
Coordinates 2856044..2856301 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS13385 2851958..2852272 + 315 WP_009937839.1 hypothetical protein -
JN136_RS13390 2852568..2853779 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
JN136_RS13395 2853906..2854565 + 660 WP_003900846.1 LppA family lipoprotein -
JN136_RS13400 2854562..2855224 + 663 WP_003901421.1 LppA family lipoprotein -
JN136_RS13405 2855221..2855499 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
JN136_RS13410 2855592..2856005 + 414 WP_003413164.1 PIN domain nuclease -
JN136_RS13415 2856044..2856301 + 258 WP_003413167.1 CopG family transcriptional regulator Antitoxin
JN136_RS13420 2856298..2856675 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS13425 2856691..2857065 - 375 WP_003413177.1 hypothetical protein -
JN136_RS13430 2857165..2857560 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
JN136_RS13435 2857557..2857802 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
JN136_RS13440 2858213..2858632 - 420 WP_003413190.1 A24 family peptidase -
JN136_RS13445 2858644..2859452 - 809 Protein_2656 shikimate dehydrogenase -
JN136_RS13450 2859449..2860702 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
JN136_RS13455 2860695..2861207 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T189747 WP_003413174.1 NZ_CP069076:2856298-2856675 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T189747 NZ_CP090967:3246851-3247384 [Edwardsiella piscicida]
ATGAATAGTGGGACAGAGTTTAAGGAGCTGAGTAAAGCTGATCACGACAGAGATTCTTTCGACTGCGGCGAAATAGAGCT
AAACAATTTTATTAAAAATTTCGCGTTAAAACACATGCGAGTGGGCATCAGTAAGACAATGGTTTTACCTGCTACTGATG
CCCTACCCAATAACAAACATCCCATCTGTGCTTTCTATACCGTAGCCCCAAGTTCAATTACCCGAAACTCACTCCCGGAC
GATCTAGGGAAGAAACTACCTCACTACCCTGTTCCCGTTTTCCTGCTTGCTCAGCTATCTGTTCACATTGACAATCAGGG
GGATGGATTAGGGAAAATAACGCTAATAAAAGCATTAGAGTATCTATGGAATGTTAACTACTTCTTACACGCTTATGCTG
TGGTAGTGGATTGTTTAAATGACAAGGCGGAGAGTTTCTACCGCAAGTATGGGTTCGAGACGCTATGCTCTTATGACGGT
CGCGTGAGGCTATTTTTACCCATGAAGACGGTAGCAGGACTGTTCTCTGACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT189747 WP_003413167.1 NZ_CP069076:2856044-2856301 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT189747 NZ_CP090967:3246585-3246854 [Edwardsiella piscicida]
ATGGCTACAGCTCGCTTAGACCTGCGGTTAGACCCAGAAATCAAAGCGAAAGCAGAGAAAGCATCCGCTCTGCTCGGTTT
AAAAACTCTAACGGAATATATCGTTCATATTGTTGATAATGATGCAAAGAGAGTAATCGCTGCGCATGAAAGCATGGCTC
TACCAAACGACATTTTTGACCAATTTATGAATGCTTGTGAGCAGGCAAAAGAGCCGAATTCTGCCCTGAAATCAGCCCTA
TCATTTACTCGTGAAAAGGGCATTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References