Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2795526..2796178 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN136_RS13130 Protein ID WP_003412752.1
Coordinates 2795753..2796178 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag JN136_RS13125 Protein ID WP_003412749.1
Coordinates 2795526..2795747 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS13110 2793766..2793972 - 207 WP_003899347.1 hypothetical protein -
JN136_RS13115 2794108..2794731 + 624 WP_003900858.1 TIGR00725 family protein -
JN136_RS13120 2794721..2795473 + 753 WP_003901416.1 hypothetical protein -
JN136_RS13125 2795526..2795747 + 222 WP_003412749.1 antitoxin Antitoxin
JN136_RS13130 2795753..2796178 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS13135 2796201..2797382 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
JN136_RS13140 2797379..2798425 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN136_RS13145 2798436..2799539 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN136_RS13150 2799798..2800619 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JN136_RS13155 2800616..2801173 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T189744 WP_003412752.1 NZ_CP069076:2795753-2796178 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T189744 NZ_CP090967:1741904-1742005 [Edwardsiella piscicida]
GCAAGGCACTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCAAAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGTTAGGTCTTTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT189744 WP_003412749.1 NZ_CP069076:2795526-2795747 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT189744 NZ_CP090967:c1742007-1741897 [Edwardsiella piscicida]
ATAAAAAAAGACCTAACACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTTTGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAGTGCCTTGCTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References