Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2398974..2399503 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN136_RS11260 Protein ID WP_003411124.1
Coordinates 2398974..2399291 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN136_RS11265 Protein ID WP_003411127.1
Coordinates 2399288..2399503 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS11230 2394111..2395187 + 1077 WP_003411110.1 hypothetical protein -
JN136_RS11235 2395184..2395465 + 282 WP_003411112.1 DUF5703 family protein -
JN136_RS11240 2395501..2396574 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
JN136_RS11245 2396579..2397109 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN136_RS11250 2397157..2398503 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN136_RS11260 2398974..2399291 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN136_RS11265 2399288..2399503 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN136_RS11270 2399758..2400816 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN136_RS11275 2400946..2401302 - 357 WP_003411130.1 hypothetical protein -
JN136_RS11280 2401397..2402179 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN136_RS11285 2402447..2402737 - 291 WP_003900476.1 YggT family protein -
JN136_RS11290 2402899..2403555 - 657 WP_003411133.1 cell division protein SepF -
JN136_RS11295 2403621..2404397 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189743 WP_003411124.1 NZ_CP069076:c2399291-2398974 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189743 NZ_CP090967:c1727658-1727329 [Edwardsiella piscicida]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189743 WP_003411127.1 NZ_CP069076:c2399503-2399288 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189743 NZ_CP090967:c1727339-1727031 [Edwardsiella piscicida]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCCGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGCCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References