Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2225813..2226711 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JN136_RS10440 Protein ID WP_003410001.1
Coordinates 2225813..2226373 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JN136_RS10445 Protein ID WP_003410003.1
Coordinates 2226370..2226711 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS10410 2220982..2221635 - 654 WP_003409976.1 cutinase Cfp21 -
JN136_RS10415 2221750..2221980 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN136_RS10420 2222065..2222976 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN136_RS10425 2223085..2223684 + 600 WP_003409989.1 L-lysine exporter -
JN136_RS10430 2224100..2224528 + 429 WP_003409992.1 cellulose-binding protein -
JN136_RS10435 2224754..2225293 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JN136_RS10440 2225813..2226373 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JN136_RS10445 2226370..2226711 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JN136_RS10450 2226797..2227054 + 258 WP_003410006.1 hypothetical protein -
JN136_RS10455 2226955..2227290 - 336 WP_003410009.1 dehydrogenase -
JN136_RS10460 2227379..2227723 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JN136_RS10465 2227717..2227965 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JN136_RS10470 2228065..2230380 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN136_RS10475 2230377..2230649 - 273 WP_003410017.1 DUF1490 family protein -
JN136_RS10480 2230702..2231058 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T189737 WP_003410001.1 NZ_CP069076:c2226373-2225813 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T189737 NZ_CP090962:1720326-1720427 [Edwardsiella piscicida]
GCAAGGCACTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCAAAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGTTAGGTCTTTTTTT

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT189737 WP_003410003.1 NZ_CP069076:c2226711-2226370 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT189737 NZ_CP090962:c1720429-1720319 [Edwardsiella piscicida]
ATAAAAAAAGACCTAACACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTTTGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAGTGCCTTGCTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References