189736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2218487..2219175 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN136_RS10395 Protein ID WP_003409958.1
Coordinates 2218487..2218906 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN136_RS10400 Protein ID WP_003409968.1
Coordinates 2218915..2219175 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS10375 2213982..2214830 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
JN136_RS10380 2214793..2216238 - 1446 WP_003899115.1 APC family permease -
JN136_RS10385 2216417..2217103 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JN136_RS10390 2217294..2218262 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN136_RS10395 2218487..2218906 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS10400 2218915..2219175 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN136_RS10405 2219318..2220994 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN136_RS10410 2220982..2221635 - 654 WP_003409976.1 cutinase Cfp21 -
JN136_RS10415 2221750..2221980 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN136_RS10420 2222065..2222976 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN136_RS10425 2223085..2223684 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189736 WP_003409958.1 NZ_CP069076:c2218906-2218487 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189736 NZ_CP090962:c1094191-1093988 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189736 WP_003409968.1 NZ_CP069076:c2219175-2218915 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189736 NZ_CP090962:c1094580-1094212 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGTTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References