Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2192260..2192804 | Replicon | chromosome |
| Accession | NZ_CP069076 | ||
| Organism | Mycobacterium tuberculosis strain N0031 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | JN136_RS10245 | Protein ID | WP_003409896.1 |
| Coordinates | 2192260..2192556 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | JN136_RS10250 | Protein ID | WP_003409899.1 |
| Coordinates | 2192553..2192804 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN136_RS10190 | 2187293..2187643 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| JN136_RS10195 | 2187654..2188556 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| JN136_RS10200 | 2188577..2188768 | - | 192 | WP_003901295.1 | hypothetical protein | - |
| JN136_RS10205 | 2188769..2189065 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN136_RS10210 | 2189305..2189520 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN136_RS10215 | 2189517..2189828 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN136_RS10220 | 2189802..2190323 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN136_RS10225 | 2190298..2190675 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| JN136_RS10230 | 2190717..2191166 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| JN136_RS10235 | 2191163..2191708 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN136_RS10240 | 2191597..2192211 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN136_RS10245 | 2192260..2192556 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JN136_RS10250 | 2192553..2192804 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JN136_RS10255 | 2192791..2193285 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN136_RS10260 | 2193445..2193852 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN136_RS10265 | 2193856..2194128 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN136_RS10270 | 2194161..2195381 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| JN136_RS10275 | 2196280..2197077 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T189735 WP_003409896.1 NZ_CP069076:c2192556-2192260 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T189735 NZ_CP090959:3547974-3548264 [Simiduia sp. 21SJ11W-1]
ATGACCTATAATCTTGAGTTTAAAAAGAGCGCTCTCAAAGAGTGGAAAAAACTAAACCCATCTGTGCGTGACATCTTTAA
GAAAAAGCTTGCTGAGCGTCTTGAGACTCCTCATGTTCCCGCCTCTGCAATTCGTGGCGGGAAAAATCTTTACAAAATAA
AACTTCGCCAGCTCGGATATCGTCTTGTCTATTCAGTAACAGACTCGACAATTACCGTAACCGTCCTTGTCGTTGGAAAA
CGAAACCGAAACGAAGTTTACGACTTGGCGCTTTCGCGCGATGAGCCATAA
ATGACCTATAATCTTGAGTTTAAAAAGAGCGCTCTCAAAGAGTGGAAAAAACTAAACCCATCTGTGCGTGACATCTTTAA
GAAAAAGCTTGCTGAGCGTCTTGAGACTCCTCATGTTCCCGCCTCTGCAATTCGTGGCGGGAAAAATCTTTACAAAATAA
AACTTCGCCAGCTCGGATATCGTCTTGTCTATTCAGTAACAGACTCGACAATTACCGTAACCGTCCTTGTCGTTGGAAAA
CGAAACCGAAACGAAGTTTACGACTTGGCGCTTTCGCGCGATGAGCCATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT189735 WP_003409899.1 NZ_CP069076:c2192804-2192553 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT189735 NZ_CP090959:3547736-3547984 [Simiduia sp. 21SJ11W-1]
GTGGCATATCAAATACTTACCGAAATGGCTGCTAGTATATCTGAGCTGAAAGCCAACCCCATGAAGGTAGTTTCCAGTGG
CGAAGGCATGCCTATCGCCGTACTAAATAGGAACGAACCCGCATTCTATTGCATTCCAGCCAAGGCCTACGAGGCCATGA
TTAATCTAATTGAGGATAAGGAGCTCCTCGAAATCGTACGCGCCAGGATAGACGAAGAGAGTATCAAGGTTCGGCTAGAT
GACCTATAA
GTGGCATATCAAATACTTACCGAAATGGCTGCTAGTATATCTGAGCTGAAAGCCAACCCCATGAAGGTAGTTTCCAGTGG
CGAAGGCATGCCTATCGCCGTACTAAATAGGAACGAACCCGCATTCTATTGCATTCCAGCCAAGGCCTACGAGGCCATGA
TTAATCTAATTGAGGATAAGGAGCTCCTCGAAATCGTACGCGCCAGGATAGACGAAGAGAGTATCAAGGTTCGGCTAGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |