Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1941434..1942047 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JN136_RS09050 Protein ID WP_003408465.1
Coordinates 1941434..1941823 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JN136_RS09055 Protein ID WP_003408469.1
Coordinates 1941820..1942047 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS09015 1937063..1937977 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JN136_RS09020 1937980..1938810 + 831 WP_003408448.1 cyclase family protein -
JN136_RS09025 1938810..1939160 + 351 WP_003898986.1 cupin domain-containing protein -
JN136_RS09030 1939213..1940031 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
JN136_RS09035 1940045..1940824 + 780 WP_003408460.1 IclR family transcriptional regulator -
JN136_RS09045 1941255..1941386 + 132 Protein_1783 IS3 family transposase -
JN136_RS09050 1941434..1941823 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS09055 1941820..1942047 - 228 WP_003408469.1 antitoxin Antitoxin
JN136_RS09060 1942265..1943749 + 1485 WP_003408473.1 biotin carboxylase -
JN136_RS09065 1943746..1944993 + 1248 WP_003408476.1 serine hydrolase -
JN136_RS09070 1945036..1945455 - 420 WP_003408483.1 hypothetical protein -
JN136_RS09075 1945445..1946155 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T189731 WP_003408465.1 NZ_CP069076:c1941823-1941434 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T189731 NZ_CP090959:1296237-1296995 [Simiduia sp. 21SJ11W-1]
ATGGCGCTTTGGGCATCGCTTGATGGGCAACAGGCCATAGGTCCGCTAACGCTTGAACTGGTGCGGGTGGTGGAATCCCA
AGAGGAAATTGCCACGCTATCGCTGGTAGACAGCATGGCAGAGCAGGATATTTTGGAGTCGCTGCTTGAAGACAGCAAGC
CCGGCCAATTGCCAGGTAACCTGCATTATTTGTTGGCCAGCCCCTTTCGCTACCCGCCGCTGCAATGGGGCAGCCGGTTT
GGCCGCACCCATGAACCCTCGCTGTTTTACGGCTCGCTCAATATTGAAACGGCGCTCACCGAATGCGCTTTTTATCGCTT
TGTATTTTTAAGCGGTGTGACAGCACCCTTCCCGAAAGCTGTGGTTTCGCAGCACACCAGTTTCAGGGTGCGCGGCCATG
GTGAGCGGGGTGTGAACTTAACGCTGCCGCCCTTTGCCGAGCACACAGACGCGTTGCGATCGCCCGAAGATTACCGGGCG
GCCCAGGCACTGGGCAGTGACATGCGCGAGGCGGGTGTACAGGTGGTTATTTACCTCTCTGCCCGCGACCGCCGTGCCAG
TGCGCTCAATGGCGCGGTGTTTGACCCTCAAGTATTTGCCAAAAGCCAACCCCAGCGCTTTCAAGCCTGGACCTGCCATG
CCACAACCGAGGCCGTGCGCTTTATTGCCGCACCTGGCGCCACCCCAGGGCGCGAGATATTTGCCTTTACCCGTGAAGAT
TTTCTGGTAGACGGGCGCCTGCCCATGCCGCCTGCTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT189731 WP_003408469.1 NZ_CP069076:c1942047-1941820 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT189731 NZ_CP090959:1295866-1296237 [Simiduia sp. 21SJ11W-1]
ATGTCAGCGTTGCAAATGAATCAGCCCGAGGCCGCTGCGGTGTTGTGTAAGGCCTTGCAGAATACCCAGCAAGCCTTTGG
CCTTACCAATGAAGAGCTGGGGCGTATTATCGGCAAAGATCGCTCCACCATTGGCCGTATGTTCGACAAGGGCCAGCTCT
CCCCCGGCTCGAAAGAGGGCGAGCTTGCGCTCTTGCTGGTGCGGGTGTATCGCAGTTTGTTTGCACTGCTGGGCGGCAGC
CAAAGCCAAATGCAGCACTGGCTGAACACCGCCAATAGCCACTTGCAGGCCACGCCACGGAGCATGATGAGCAGCGTGCA
GGGCCTTGTGAATTTGGTGACCTACCTGGATGCCATGCGTGGGCGCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References