Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1574641..1575296 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag JN136_RS07440 Protein ID WP_003898861.1
Coordinates 1574641..1575042 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag JN136_RS07445 Protein ID WP_003407272.1
Coordinates 1575039..1575296 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS07425 1570116..1571501 - 1386 WP_017487694.1 cytochrome P450 -
JN136_RS07430 1571579..1572613 + 1035 WP_003407264.1 AraC family transcriptional regulator -
JN136_RS07435 1572659..1574386 - 1728 Protein_1463 PE family protein -
JN136_RS07440 1574641..1575042 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS07445 1575039..1575296 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
JN136_RS07450 1575379..1576338 - 960 WP_003407276.1 alpha/beta hydrolase -
JN136_RS07455 1576363..1577325 - 963 WP_003407279.1 alpha/beta hydrolase -
JN136_RS07460 1577324..1578061 + 738 WP_031647000.1 lysoplasmalogenase -
JN136_RS07465 1578142..1580109 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T189728 WP_003898861.1 NZ_CP069076:c1575042-1574641 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T189728 NZ_CP090954:c4717661-4717527 [Xanthomonas arboricola pv. pruni]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT189728 WP_003407272.1 NZ_CP069076:c1575296-1575039 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT189728 NZ_CP090954:c4717896-4717744 [Xanthomonas arboricola pv. pruni]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References