Detailed information of TA system TA189726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1388884..1389443
• Replicon: chromosome
• Accession: NZ_CP069076
• Organism: Mycobacterium tuberculosis strain N0031

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: JN136_RS06625
• Protein ID: WP_003898789.1
• Coordinates: 1388884..1389177 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JN136_RS06630
• Protein ID: WP_003406322.1
• Coordinates: 1389174..1389443 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN136_RS06600	1384583..1384843	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
JN136_RS06605	1384840..1385271	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JN136_RS06610	1385294..1386876	-	1583	Protein_1305	PE family protein	-
JN136_RS06615	1387056..1387916	+	861	WP_003901118.1	glycine betaine ABC transporter substrate-binding protein	-
JN136_RS06620	1387997..1388827	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JN136_RS06625	1388884..1389177	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JN136_RS06630	1389174..1389443	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN136_RS06635	1389556..1393251	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JN136_RS06640	1393393..1394181	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T189726 WP_003898789.1 NZ_CP069076:c1389177-1388884 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T189726 NZ_CP090953:1784866-1785051 [Sphingomonas sp. S2-65]
ATGAAGAGCCGGGAAGTCATCAAGAAGATCGAGGCGGAAGGCTGGTACGAAGTGCGTCAGACCGGGAGTCACAAGCACTT
CCGCCACCCAACCCGCCCCGGCACGGCGACGGTCCCGCATCCCAAGAGCGACCTGCCAATCGGAACGCTCAAGAGCATCA
GCAAGCAGACTGGGGTGCCCCTCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT189726 WP_003406322.1 NZ_CP069076:c1389443-1389174 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT189726 NZ_CP090953:1785097-1785489 [Sphingomonas sp. S2-65]
ATGGCGACCGCCTACTATCCAGCGATCATCGAGCGAGGCCCCGAGGGCTTTGGCGTCTATTTCCCGGACCTCCCCGGCTG
CGTGTCTGCCGGGCGCACGGTGACCGAAGCCGCACTTGGCGCCGAAGAGGCTCTTCATGGGCACCTCGCCGTTATGGCCG
AGCATGGCGATGCTATCCCCGAGGCTTCGGCGGTTGATGAGGTCGAGGCGTTCGAGGGTAGTGAGGAAGTTGCTCGCATC
CTCGTCCGCGGCGAACGCCCAGGCAAAGCGGTCCGGGTGCAGATCTCGATAGAGGAAGGCCTGCTCGCGCGAATTGATCG
GGTCGCCGCCAACCGCTCGCGCTTCCTCGCTGAAGCCGCCGCCGCCAAGCTCGCGGCAGTAGCGGCGATCTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2