189711

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 699707..700350 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN136_RS03175 Protein ID WP_003403187.1
Coordinates 699949..700350 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN136_RS03170 Protein ID WP_003403184.1
Coordinates 699707..699952 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS03135 694987..695517 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN136_RS03140 695501..696196 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN136_RS03145 696319..696630 + 312 WP_003403164.1 hypothetical protein -
JN136_RS03150 696702..697652 + 951 WP_003900184.1 DUF1259 domain-containing protein -
JN136_RS03155 697893..698477 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN136_RS03160 698479..699189 + 711 Protein_626 IS607 family element RNA-guided endonuclease TnpB -
JN136_RS03165 699192..699662 + 471 WP_003898523.1 hypothetical protein -
JN136_RS03170 699707..699952 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN136_RS03175 699949..700350 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS03180 700341..700520 + 180 Protein_630 hypothetical protein -
JN136_RS03185 700938..701135 - 198 WP_003403191.1 hypothetical protein -
JN136_RS03190 701215..702372 - 1158 WP_003898524.1 hypothetical protein -
JN136_RS03195 702424..702645 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN136_RS03200 702787..703392 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189711 WP_003403187.1 NZ_CP069076:699949-700350 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189711 NZ_CP090931:c4725226-4724942 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189711 WP_003403184.1 NZ_CP069076:699707-699952 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189711 NZ_CP090931:c4725458-4725216 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References