Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 691302..691948 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag JN136_RS03105 Protein ID WP_003403122.1
Coordinates 691302..691694 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag JN136_RS03110 Protein ID WP_003403125.1
Coordinates 691691..691948 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS03090 686964..688490 + 1527 WP_003403112.1 virulence factor Mce family protein -
JN136_RS03095 688553..689695 + 1143 WP_049958386.1 virulence factor Mce family protein -
JN136_RS03100 689700..691250 + 1551 WP_003403119.1 MlaD family protein -
JN136_RS03105 691302..691694 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
JN136_RS03110 691691..691948 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
JN136_RS03115 692131..693366 - 1236 WP_003403128.1 ATP-binding protein -
JN136_RS03120 693617..694030 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
JN136_RS03125 694027..694263 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
JN136_RS03130 694367..694873 - 507 WP_003900973.1 two component system sensor kinase HK1 -
JN136_RS03135 694987..695517 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN136_RS03140 695501..696196 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN136_RS03145 696319..696630 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T189709 WP_003403122.1 NZ_CP069076:c691694-691302 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T189709 NZ_CP090931:4010561-4010779 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT189709 WP_003403125.1 NZ_CP069076:c691948-691691 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT189709 NZ_CP090931:4010160-4010534 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References