Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 636700..637376 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag JN136_RS02870 Protein ID WP_003898500.1
Coordinates 636700..637113 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag JN136_RS02875 Protein ID WP_003402915.1
Coordinates 637110..637376 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS02840 632045..632347 - 303 WP_003402896.1 DUF3349 domain-containing protein -
JN136_RS02845 632407..632685 - 279 WP_003402901.1 hypothetical protein -
JN136_RS02850 632682..633935 - 1254 WP_003402904.1 inorganic phosphate transporter -
JN136_RS02855 634055..634441 - 387 WP_003402907.1 VOC family protein -
JN136_RS02860 634504..635388 - 885 WP_003402909.1 SDR family oxidoreductase -
JN136_RS02865 635484..636386 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
JN136_RS02870 636700..637113 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS02875 637110..637376 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JN136_RS02880 637568..639283 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
JN136_RS02885 639361..640965 + 1605 WP_003900961.1 amidohydrolase -
JN136_RS02890 640962..641942 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T189707 WP_003898500.1 NZ_CP069076:c637113-636700 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T189707 NZ_CP090931:1943878-1943980 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT189707 WP_003402915.1 NZ_CP069076:c637376-637110 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT189707 NZ_CP090931:c1943987-1943842 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References