Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2937192..2937906 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag JN138_RS13805 Protein ID WP_003413460.1
Coordinates 2937466..2937906 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag JN138_RS13800 Protein ID WP_003413456.1
Coordinates 2937192..2937479 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS13765 2932614..2932859 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JN138_RS13770 2932856..2933260 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
JN138_RS13775 2933477..2934097 + 621 WP_003413441.1 DUF4178 domain-containing protein -
JN138_RS13780 2934108..2934602 + 495 WP_003413444.1 DUF2617 family protein -
JN138_RS13785 2934599..2935030 + 432 WP_003899390.1 DUF4247 domain-containing protein -
JN138_RS13790 2935055..2935513 + 459 WP_003413451.1 DUF350 domain-containing protein -
JN138_RS13795 2935510..2937081 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
JN138_RS13800 2937192..2937479 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
JN138_RS13805 2937466..2937906 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
JN138_RS13810 2937927..2938682 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
JN138_RS13815 2938815..2939411 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
JN138_RS13820 2939419..2940264 - 846 WP_003413466.1 acyl-CoA thioesterase II -
JN138_RS13825 2940293..2941192 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
JN138_RS13830 2941320..2941994 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T189688 WP_003413460.1 NZ_CP069075:2937466-2937906 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T189688 NZ_CP090929:4827799-4828110 [Salmonella enterica subsp. enterica serovar Agona]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTAACTGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT189688 WP_003413456.1 NZ_CP069075:2937192-2937479 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT189688 NZ_CP090929:4828107-4828553 [Salmonella enterica subsp. enterica serovar Agona]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGCTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References