Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2875732..2876363 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag JN138_RS13530 Protein ID WP_003413174.1
Coordinates 2875986..2876363 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag JN138_RS13525 Protein ID WP_003413167.1
Coordinates 2875732..2875989 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS13495 2871646..2871960 + 315 WP_009937839.1 hypothetical protein -
JN138_RS13500 2872256..2873467 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
JN138_RS13505 2873594..2874253 + 660 WP_003900846.1 LppA family lipoprotein -
JN138_RS13510 2874250..2874912 + 663 WP_023643170.1 LppA family lipoprotein -
JN138_RS13515 2874909..2875187 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
JN138_RS13520 2875280..2875693 + 414 WP_003413164.1 PIN domain nuclease -
JN138_RS13525 2875732..2875989 + 258 WP_003413167.1 CopG family transcriptional regulator Antitoxin
JN138_RS13530 2875986..2876363 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
JN138_RS13535 2876379..2876753 - 375 WP_003413177.1 hypothetical protein -
JN138_RS13540 2876853..2877248 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
JN138_RS13545 2877245..2877490 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
JN138_RS13550 2877901..2878320 - 420 WP_003413190.1 A24 family peptidase -
JN138_RS13555 2878332..2879141 - 810 WP_003413193.1 shikimate dehydrogenase -
JN138_RS13560 2879138..2880391 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
JN138_RS13565 2880384..2880896 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T189686 WP_003413174.1 NZ_CP069075:2875986-2876363 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T189686 NZ_CP090929:4364928-4365344 [Salmonella enterica subsp. enterica serovar Agona]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCGGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT189686 WP_003413167.1 NZ_CP069075:2875732-2875989 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT189686 NZ_CP090929:4364701-4364931 [Salmonella enterica subsp. enterica serovar Agona]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References