Detailed information of TA system TA189684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2861393..2862033
• Replicon: chromosome
• Accession: NZ_CP069075
• Organism: Mycobacterium tuberculosis strain N0004

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: JN138_RS13435
• Protein ID: WP_003412970.1
• Coordinates: 2861393..2861812 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN138_RS13440
• Protein ID: WP_244694653.1
• Coordinates: 2861809..2862033 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN138_RS13405	2856978..2857700	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
JN138_RS13410	2858217..2858444	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
JN138_RS13415	2858441..2858842	+	402	WP_003412963.1	PIN domain-containing protein	-
JN138_RS13420	2858877..2859797	-	921	WP_003412965.1	restriction endonuclease	-
JN138_RS13425	2860138..2860344	-	207	WP_229298035.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
JN138_RS13430	2860442..2861392	+	951	WP_003911916.1	ERCC4 domain-containing protein	-
JN138_RS13435	2861393..2861812	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN138_RS13440	2861809..2862033	-	225	WP_244694653.1	antitoxin	Antitoxin
JN138_RS13445	2862064..2864907	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
JN138_RS13450	2864979..2865380	-	402	WP_003412981.1	hypothetical protein	-
JN138_RS13455	2865380..2865850	-	471	WP_003899364.1	transcription antitermination factor NusB	-
JN138_RS13460	2865853..2866416	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T189684 WP_003412970.1 NZ_CP069075:c2861812-2861393 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T189684 NZ_CP090929:c4308653-4307325 [Salmonella enterica subsp. enterica serovar Agona]
ATGCGTCGAACACAGCAGCGTTTATCAATATGGATGAATGGAATCCGGGTCGGATTCTGGGAGAAGGCCAGAGGCGAGGA
TTTATTACAATACCTTCCAGAATGGATAATTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCCTTTCACTCCAGGTA
ATCAGCTTTGGCGTGGTAATGTTGTTCGTGACTATTTTGATAATTTATTGCCTGACAGCGAAAGTATACGCAGACGTTTA
GCCGTGCGTTACCAGGCTGAAAGCCTTGAGCCTTTTGATCTATTGGCTGAGCTGGGAAGAGACTGCGTTGGTGCAATACA
GTTACTGAATGTTGATGAAGAGCCCACAGATTTATTTTCCGTAAATTATCGCCCACTTTCTGAAGCTGATATCGCAACTA
CATTGCGTAATACTACGGCGATATCGTTGCCTGGTCGGCAGGACGAAACTGACGATTTGCGATTATCAATTGCCGGTGCG
CAGGAAAAAACGGCTTTATTGTGGCATGAAGAACGATGGTGTTTACCTGAAGGTAATACCCCAACAACGCATATCTTCAA
ACTACCGCTTGGGTTGGTTGGGAACATGCAAGCGGATATGAGTACATCGGTTGAAAATGAATGGCTGTGTTCTTTGCTTG
TTGAGCACTACGGGATCCCTGTAGCAAAAACACAGATTGCGCAGTTTGAGGATCAGAAGGCATTAGTAGTTGAGCGTTTC
GACAGAAGATGGTCAGGCGATCGGCAATGGATCATTCGTTTGCCACAAGAGGATATGTGTCAGGCTTTAGGTGTTTCTCC
GTTACGAAAATACCAGTCTGATGGTGGGCCGGGTATTTCCGATATTATGGAAATACTGAGTCATTCAGATCAGGCTGAGC
AGGACAAAGAGCAGTTCTTCAGGGCTCAAATTATTTTCTGGTTGATGGCTGCTACTGACGGCCATGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAAGTCGTTACCACCTTACGCCTCTTTACGATATTTTATCAGCATGGCCGGTAATTGGTCATGG
TAATAATCAGATTTCCTGGCAAAGATGCAAACTGGCAATGGCTGTTCGCGGTAGCAGTAATTATTACCACATTTATAGAG
TTCAACGACGGCATTGGATTAATCAAGGTGAATTAAACGGATTGGGAAGACGACAAGTTGAGTCCATGATGGATGACATT
ATATCCAGCACACCTGAAGTCATTGAGCGTGTATCTGCGTTGCTTCCAGAGTCGTTTCCATCTGAGCTTGCTGAGTGTAT
TTTTGAAGGTATGCGGCAGCAGTGTAGGCGTTTGGCTGGAAGGGAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7992.95 Da
• Isoelectric Point: 4.0684

>AT189684 WP_244694653.1 NZ_CP069075:c2862033-2861809 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDNV

Nucleotide

• Length: 225 bp

>AT189684 NZ_CP090929:c4308963-4308658 [Salmonella enterica subsp. enterica serovar Agona]
ATGAATACTGTTTATCCGTTGAAAACTTTGAATCAAATTCGTCCATTGCTGATTGGCTTTCGCAAGGCTAATGGACTGAC
ACAAAAGGAAGTTTCTGAAAGGTTAGGAGTAACTCAGCAAACTTATGCCCGACTGGAAGCGAATCCAGCCAGTGCCAGTA
TGGAGCGACTATTCAGGGTATTTACCGTGCTGGGTGTAGAAATGGTACTCTCTTCTGGGCCACAGATACTTTCTTCGATG
TCATCTTCAACAATGGAAGAGTCAGAACAGCAAATAGATTCACCTGCCAGACGGGAAAAATGGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08