Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2411986..2412515 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN138_RS11345 Protein ID WP_003411124.1
Coordinates 2411986..2412303 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN138_RS11350 Protein ID WP_003411127.1
Coordinates 2412300..2412515 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS11315 2407123..2408199 + 1077 WP_003411110.1 hypothetical protein -
JN138_RS11320 2408196..2408477 + 282 WP_003411112.1 DUF5703 family protein -
JN138_RS11325 2408513..2409586 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN138_RS11330 2409591..2410121 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN138_RS11335 2410169..2411515 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN138_RS11345 2411986..2412303 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN138_RS11350 2412300..2412515 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN138_RS11355 2412770..2413828 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN138_RS11360 2413958..2414314 - 357 WP_003411130.1 hypothetical protein -
JN138_RS11365 2414409..2415191 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN138_RS11370 2415459..2415749 - 291 WP_003900476.1 YggT family protein -
JN138_RS11375 2415911..2416567 - 657 WP_003411133.1 cell division protein SepF -
JN138_RS11380 2416633..2417409 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189682 WP_003411124.1 NZ_CP069075:c2412303-2411986 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189682 NZ_CP090929:3645153-3645371 [Salmonella enterica subsp. enterica serovar Agona]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189682 WP_003411127.1 NZ_CP069075:c2412515-2412300 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189682 NZ_CP090929:3644751-3645125 [Salmonella enterica subsp. enterica serovar Agona]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References