Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2375128..2375823 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN138_RS11135 Protein ID WP_003410811.1
Coordinates 2375128..2375562 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN138_RS11140 Protein ID WP_003410814.1
Coordinates 2375569..2375823 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS11125 2371282..2374323 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JN138_RS11130 2374316..2375149 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN138_RS11135 2375128..2375562 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN138_RS11140 2375569..2375823 - 255 WP_003410814.1 antitoxin Antitoxin
JN138_RS11145 2375839..2376096 - 258 WP_003410816.1 hypothetical protein -
JN138_RS11150 2377042..2377338 + 297 WP_003410820.1 PE family protein -
JN138_RS11155 2377394..2378125 + 732 WP_003900467.1 PPE family protein -
JN138_RS11160 2378665..2379411 - 747 WP_003901330.1 proteasome subunit alpha -
JN138_RS11165 2379408..2380283 - 876 WP_003411023.1 proteasome subunit beta -
JN138_RS11170 2380280..2380474 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T189681 WP_003410811.1 NZ_CP069075:c2375562-2375128 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T189681 NZ_CP090929:c2918002-2917899 [Salmonella enterica subsp. enterica serovar Agona]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT189681 WP_003410814.1 NZ_CP069075:c2375823-2375569 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT189681 NZ_CP090929:2917897-2918040 [Salmonella enterica subsp. enterica serovar Agona]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References