Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2236241..2237139 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JN138_RS10515 Protein ID WP_003410001.1
Coordinates 2236241..2236801 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JN138_RS10520 Protein ID WP_003410003.1
Coordinates 2236798..2237139 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS10485 2231410..2232063 - 654 WP_003409976.1 cutinase Cfp21 -
JN138_RS10490 2232178..2232408 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN138_RS10495 2232493..2233404 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN138_RS10500 2233513..2234112 + 600 WP_003409989.1 L-lysine exporter -
JN138_RS10505 2234528..2234956 + 429 WP_003409992.1 cellulose-binding protein -
JN138_RS10510 2235182..2235721 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JN138_RS10515 2236241..2236801 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JN138_RS10520 2236798..2237139 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JN138_RS10525 2237225..2237482 + 258 WP_003410006.1 hypothetical protein -
JN138_RS10530 2237383..2237718 - 336 WP_003410009.1 dehydrogenase -
JN138_RS10535 2237807..2238151 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JN138_RS10540 2238145..2238393 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JN138_RS10545 2238493..2240745 - 2253 WP_016719189.1 cation transporter ATPase CptG -
JN138_RS10550 2240742..2241014 - 273 WP_003410017.1 DUF1490 family protein -
JN138_RS10555 2241067..2241423 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T189676 WP_003410001.1 NZ_CP069075:c2236801-2236241 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T189676 NZ_CP090929:872969-873382 [Salmonella enterica subsp. enterica serovar Agona]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT189676 WP_003410003.1 NZ_CP069075:c2237139-2236798 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT189676 NZ_CP090929:872722-872988 [Salmonella enterica subsp. enterica serovar Agona]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References