Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1770591..1771204 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag JN138_RS08325 Protein ID WP_003407786.1
Coordinates 1770800..1771204 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag JN138_RS08320 Protein ID WP_009935474.1
Coordinates 1770591..1770794 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS08290 1765996..1766376 + 381 WP_003407768.1 fumarate reductase subunit C -
JN138_RS08295 1766373..1766750 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
JN138_RS08300 1766818..1767426 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
JN138_RS08305 1767610..1768758 + 1149 Protein_1638 MMPL family transporter -
JN138_RS08310 1768768..1769214 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
JN138_RS08315 1769249..1770538 + 1290 WP_016719220.1 threonine ammonia-lyase -
JN138_RS08320 1770591..1770794 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN138_RS08325 1770800..1771204 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
JN138_RS08330 1771221..1772963 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
JN138_RS08335 1772956..1775253 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T189669 WP_003407786.1 NZ_CP069075:1770800-1771204 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T189669 NZ_CP090916:38973-39239 [Staphylococcus epidermidis]
ATGGCTAAATATAAAATCAACATAAAGAATTCAGCGAAGACAGATTTGAAGAAGATAAAACGTTCTCACTTACAAGAACA
ATTTTTGAAAATCGTAGAAATACTAAAATATGATCCATATCAACAAAGTCAATCCTTTGAAAAATTGCATCCTAAACATT
TAGGACGATACTCAAGACGTATCAATCATCAACATAGAGTTGTCTATACAATTGATGAGGAAAATAAAGAAGTATTAATA
TTAGCAGCTTGGTCTCATTATGAATGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT189669 WP_009935474.1 NZ_CP069075:1770591-1770794 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT189669 NZ_CP090916:38716-38973 [Staphylococcus epidermidis]
ATGAAAAGTAAAACACCAACAGAAGCTCGTAAAGATTTTTATCAGTTATTAAAACGTGTCAATAATGACCATGAACCAGT
ATATATTGAAGGCAAATATGATGAGAGTAATGCTGTTATTATAGGCATGGAAGATTGGCGTAGCATTAATGAAACGATAT
ATCTTGAGGCTACAGGCACAATGGACAAAGTTAGAGAACGTGAGCATGACAACAGTGGTTATACAAACATAGGTGATATT
GATTGGGCTAGACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References