Detailed information of TA system TA189665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1393313..1393872
• Replicon: chromosome
• Accession: NZ_CP069075
• Organism: Mycobacterium tuberculosis strain N0004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: JN138_RS06665
• Protein ID: WP_003898789.1
• Coordinates: 1393313..1393606 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JN138_RS06670
• Protein ID: WP_003406322.1
• Coordinates: 1393603..1393872 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN138_RS06640	1388908..1389168	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
JN138_RS06645	1389165..1389596	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JN138_RS06650	1389619..1391305	-	1687	Protein_1313	PE family protein	-
JN138_RS06655	1391485..1392345	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
JN138_RS06660	1392426..1393256	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JN138_RS06665	1393313..1393606	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JN138_RS06670	1393603..1393872	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN138_RS06675	1393985..1397680	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JN138_RS06680	1397822..1398610	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T189665 WP_003898789.1 NZ_CP069075:c1393606-1393313 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T189665 NZ_CP090915:c1001600-1001136 [Staphylococcus epidermidis]
GTGGGGAAATATGAGGATATGTTAATTGAACATGACTATATTGAAGTCATCGAATGTGATAAATTACCTAATGACTTATA
TGGTTTATGGCTTGGGGATATGATTTTAATTAATCGTAATCTACCTATCACTTCCAAACTTGAAACACTTGCAGAGGAGC
TTGCTCATAATGAACTTACATACGGAAATATAGCTAATCAGAATAATTTTAATCATAGAAAATTTGAAGGTTATGCACGT
AAGTTAGCCTATGAAAAATTAGTCCCTCTTAAAGATATTGTAAAAGCATTTTTGCAAGACATTCATAACTTATATGAACT
TGCTAATTTTTTTGAAGTTACAGAAAGTTTTGTAATACAAAGTATTGAACATTATAAACAAAAACATGGATATTCCACTC
GGTATGGTAAATACGTTATTCAATTTGAGCCATTACGGGTGTTTGAATATAAAAATATAGAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT189665 WP_003406322.1 NZ_CP069075:c1393872-1393603 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT189665 NZ_CP090915:c1001942-1001613 [Staphylococcus epidermidis]
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTAGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAACTTAACTAGAGAATTTCCGTTAAATCGTACAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATACTTACTTGGTTTTGACAAAAGTGAACAACAAGATGAACAACCAAAACAT
CGTGCAGCTCATCTTGAAGGTGAATTAACAGATGAAGAATGGCAACGTGTATTAGATTATGCAGATTATATAAGAAGTAA
ACGCAAATAA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2