Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 709417..710060 | Replicon | chromosome |
Accession | NZ_CP069075 | ||
Organism | Mycobacterium tuberculosis strain N0004 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P67239 |
Locus tag | JN138_RS03240 | Protein ID | WP_003403187.1 |
Coordinates | 709659..710060 (+) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TQ91 |
Locus tag | JN138_RS03235 | Protein ID | WP_003403184.1 |
Coordinates | 709417..709662 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN138_RS03200 | 704697..705227 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
JN138_RS03205 | 705211..705906 | - | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
JN138_RS03210 | 706029..706340 | + | 312 | WP_003403164.1 | hypothetical protein | - |
JN138_RS03215 | 706412..707362 | + | 951 | WP_003900184.1 | DUF1259 domain-containing protein | - |
JN138_RS03220 | 707603..708187 | + | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
JN138_RS03225 | 708189..708899 | + | 711 | Protein_639 | IS607 family element RNA-guided endonuclease TnpB | - |
JN138_RS03230 | 708902..709372 | + | 471 | WP_003898523.1 | hypothetical protein | - |
JN138_RS03235 | 709417..709662 | + | 246 | WP_003403184.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
JN138_RS03240 | 709659..710060 | + | 402 | WP_003403187.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JN138_RS03245 | 710051..710230 | + | 180 | Protein_643 | hypothetical protein | - |
JN138_RS03250 | 710648..710845 | - | 198 | WP_003403191.1 | hypothetical protein | - |
JN138_RS03255 | 710925..712082 | - | 1158 | WP_003898524.1 | hypothetical protein | - |
JN138_RS03260 | 712134..712355 | - | 222 | WP_003898525.1 | DUF4926 domain-containing protein | - |
JN138_RS03265 | 712497..713102 | + | 606 | WP_003898526.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14501.21 Da Isoelectric Point: 4.4463
>T189651 WP_003403187.1 NZ_CP069075:709659-710060 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
Download Length: 402 bp
>T189651 NZ_CP090909:c3043316-3043029 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTAGGTTAACAATCAAACCCTCTGGGGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTAGGTTAACAATCAAACCCTCTGGGGATTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8813.12 Da Isoelectric Point: 10.3486
>AT189651 WP_003403184.1 NZ_CP069075:709417-709662 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
Download Length: 246 bp
>AT189651 NZ_CP090909:c3043625-3043323 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ91 |