Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 709417..710060 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN138_RS03240 Protein ID WP_003403187.1
Coordinates 709659..710060 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN138_RS03235 Protein ID WP_003403184.1
Coordinates 709417..709662 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS03200 704697..705227 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN138_RS03205 705211..705906 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN138_RS03210 706029..706340 + 312 WP_003403164.1 hypothetical protein -
JN138_RS03215 706412..707362 + 951 WP_003900184.1 DUF1259 domain-containing protein -
JN138_RS03220 707603..708187 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN138_RS03225 708189..708899 + 711 Protein_639 IS607 family element RNA-guided endonuclease TnpB -
JN138_RS03230 708902..709372 + 471 WP_003898523.1 hypothetical protein -
JN138_RS03235 709417..709662 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN138_RS03240 709659..710060 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN138_RS03245 710051..710230 + 180 Protein_643 hypothetical protein -
JN138_RS03250 710648..710845 - 198 WP_003403191.1 hypothetical protein -
JN138_RS03255 710925..712082 - 1158 WP_003898524.1 hypothetical protein -
JN138_RS03260 712134..712355 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN138_RS03265 712497..713102 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189651 WP_003403187.1 NZ_CP069075:709659-710060 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189651 NZ_CP090909:c3043316-3043029 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTAGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189651 WP_003403184.1 NZ_CP069075:709417-709662 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189651 NZ_CP090909:c3043625-3043323 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References