Detailed information of TA system TA189643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 366842..367368
• Replicon: chromosome
• Accession: NZ_CP069075
• Organism: Mycobacterium tuberculosis strain N0004

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: JN138_RS01600
• Protein ID: WP_015629470.1
• Coordinates: 367066..367368 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: JN138_RS01595
• Protein ID: WP_003401555.1
• Coordinates: 366842..367069 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN138_RS01580	362535..363338	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
JN138_RS01585	363348..364745	-	1398	WP_003401544.1	sulfatase	-
JN138_RS01590	364924..366699	+	1776	WP_010886074.1	PE family protein	-
JN138_RS01595	366842..367069	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
JN138_RS01600	367066..367368	+	303	WP_015629470.1	toxin-antitoxin system toxin	Toxin
JN138_RS01605	367416..367637	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
JN138_RS01610	367634..368059	+	426	WP_003401566.1	PIN domain nuclease	-
JN138_RS01615	368195..368827	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
JN138_RS01620	368824..369732	+	909	WP_244694882.1	SDR family NAD(P)-dependent oxidoreductase	-
JN138_RS01625	369740..370330	-	591	WP_229298012.1	hypothetical protein	-
JN138_RS01630	370323..370373	-	51	Protein_322	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10472.19 Da
• Isoelectric Point: 4.9609

>T189643 WP_015629470.1 NZ_CP069075:367066-367368 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRATDTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T189643 NZ_CP090908:c4415902-4415480 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTAACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGATCGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGACTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAATGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGAATCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT189643 WP_003401555.1 NZ_CP069075:366842-367069 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT189643 NZ_CP090908:c4416149-4415883 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATTTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1