Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3730933..3731607 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JN139_RS17665 Protein ID WP_003417282.1
Coordinates 3730933..3731361 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JN139_RS17670 Protein ID WP_003417286.1
Coordinates 3731365..3731607 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS17640 3726755..3727156 - 402 WP_003417264.1 cytidine deaminase -
JN139_RS17645 3727393..3727731 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
JN139_RS17650 3727728..3728162 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JN139_RS17655 3728291..3730063 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JN139_RS17660 3730063..3730854 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JN139_RS17665 3730933..3731361 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JN139_RS17670 3731365..3731607 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
JN139_RS17675 3731729..3732343 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JN139_RS17680 3732340..3733005 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JN139_RS17685 3733006..3733539 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JN139_RS17690 3733536..3733910 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JN139_RS17695 3734007..3735011 - 1005 WP_244703704.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T189638 WP_003417282.1 NZ_CP069074:c3731361-3730933 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T189638 NZ_CP090908:c3186958-3186560 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCGTTCAA
TCGCTATGCGGGCAAAATGGTCATTTCGTCGGTCACCTATGGCGAATTGGTTCACGGAGTGGAGAAAAGCTCGCGTCCGG
CGGTTAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACGGCGCCAAAGCGGCTTCGCACTAC
GGCAACATTCGGGCTGCGCTGGAACGTCAGGGAACGCCTATTGGCGTAAACGATCTGCATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATTCTGGTGACCAATAACCGACGCGAATTTGAGCGCGTTGATGGCTTACGGCTGGAAAATTGGCTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT189638 WP_003417286.1 NZ_CP069074:c3731607-3731365 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT189638 NZ_CP090908:c3187191-3186958 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACGCAGGCCGTGCGCTTGCCTGCAGAGGTGCGTTTCCCCGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCGCCGGTGGAGAATACCTGGGACAGTTTCTTCTGCG
CGGAAAATGAGGTGAGCGATGACTTCCTCAATGAACGTGCCGGGCAACACCAGCGCGAGCGGGAAGAACTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References