Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2833988..2834640 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN139_RS13320 Protein ID WP_003412752.1
Coordinates 2834215..2834640 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag JN139_RS13315 Protein ID WP_003412749.1
Coordinates 2833988..2834209 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS13300 2832228..2832434 - 207 WP_003899347.1 hypothetical protein -
JN139_RS13305 2832570..2833193 + 624 WP_003900858.1 TIGR00725 family protein -
JN139_RS13310 2833183..2833935 + 753 WP_003901416.1 hypothetical protein -
JN139_RS13315 2833988..2834209 + 222 WP_003412749.1 antitoxin Antitoxin
JN139_RS13320 2834215..2834640 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN139_RS13325 2834663..2835844 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
JN139_RS13330 2835841..2836887 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN139_RS13335 2836898..2838001 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN139_RS13340 2838260..2839081 - 822 WP_031747419.1 citrate (pro-3S)-lyase subunit beta -
JN139_RS13345 2839078..2839635 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T189623 WP_003412752.1 NZ_CP069074:2834215-2834640 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T189623 NZ_CP090898:728473-728733 [Synechococcus sp. NB0720_010]
ATGCAGGTGGTCAGCTTTTCAGAAGCGCGCCAGAGCTTCAAAGCCGTCCTGGATCGAGTCGAGGCCGATGCGGACGTCAC
CTTGATCACCCGGCGGGATGCCAGCAGCGCCGTCCTGATGTCCCTCGAGACCTACAACAGCCTGATGGAGACCGTGCACC
TGCTGCGCAGTCCCGCCAACGCCGCCCACCTGCAACAGTCCCTCGAGCAAGCCGACCGCGGGGAGTTGGTCGATCACGCA
TTGATCGATGCCGAGCCTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT189623 WP_003412749.1 NZ_CP069074:2833988-2834209 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT189623 NZ_CP090898:728720-728992 [Synechococcus sp. NB0720_010]
ATGCCGAGCCTTGAACGACTCAGCTGGACCACTGCGGCCTGGGGCGACTACCTCTACTGGCAGGGACAGGACCGCAAAAC
CCTTAGGCGCATCAACCAACTGATCCAGGCCTGCCTGAGGCACCCGTTTGAGGGCATTGGCAAGCCAGAGCCCCTCAGGG
AATCCCTCTCAGGTTGCTGGTCCAGGCGCATCGATGCAGAGCATCGGCTCGTCTACCGCGTCGACGGCCCTCTCCTGGTG
ATCCTGGCCTGCCGCTACCACTACCGCGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References