Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2430774..2431303 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN139_RS11435 Protein ID WP_003411124.1
Coordinates 2430774..2431091 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN139_RS11440 Protein ID WP_003411127.1
Coordinates 2431088..2431303 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS11405 2425795..2426871 + 1077 WP_003411110.1 hypothetical protein -
JN139_RS11410 2426868..2427149 + 282 WP_003411112.1 DUF5703 family protein -
JN139_RS11415 2427185..2428258 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN139_RS11420 2428263..2428793 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN139_RS11425 2428841..2430187 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN139_RS11435 2430774..2431091 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN139_RS11440 2431088..2431303 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN139_RS11445 2431558..2432616 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN139_RS11450 2432746..2433102 - 357 WP_003411130.1 hypothetical protein -
JN139_RS11455 2433197..2433979 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN139_RS11460 2434247..2434537 - 291 WP_003900476.1 YggT family protein -
JN139_RS11465 2434699..2435355 - 657 WP_003411133.1 cell division protein SepF -
JN139_RS11470 2435421..2436197 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189622 WP_003411124.1 NZ_CP069074:c2431091-2430774 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189622 NZ_CP090898:631133-631357 [Synechococcus sp. NB0720_010]
ATCCCCCGCTTTCAGGCCTTCGAACGGGTGGCCCGGCGCAAGCTTCGCCAGCTGGACATTGCCTCGCGCCTGGAGGATCT
GCGCATTCCCCCCGGCAATCGACTGGAAGCACTGCGCGGCGACCGAGCTGGAGAACACAGCATCCGGATCAACGACCAAT
TCCGCCTTTGCTTTGTTTGGTCAGATTCCGGCCCTGAAGCCGTTGAGATCGTTGATTACCACTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189622 WP_003411127.1 NZ_CP069074:c2431303-2431088 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189622 NZ_CP090898:631357-631659 [Synechococcus sp. NB0720_010]
ATGACTGCCACACATCGCCTAAGCCCCATTACCCCAGGTGAACTGCTCGTTGAGGAGTTTCTGGTTCCGCTTGGGGTCAG
CCAGTACCGACTGTCGAAGGCCATCAAGGTGCCGGCATCCAGGATCAGCGAAATCGTCTCCGGTCAGCGATCGATCAGTG
CTGATACAGACCTGCGACTCTGCCGCTTCCTGGGCCTCAGTCCCGGGTACTGGCTTCGTGCTCAAGCCGCCTACGACACA
GAGATTGCCGGAGCGGAGCTCGCTGAGGAGATCGCCAAGATTCAGCCCTTGGTGAGCAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References