Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2393741..2394436 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN139_RS11225 Protein ID WP_003410811.1
Coordinates 2393741..2394175 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN139_RS11230 Protein ID WP_003410814.1
Coordinates 2394182..2394436 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS11215 2389895..2392936 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JN139_RS11220 2392929..2393762 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN139_RS11225 2393741..2394175 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN139_RS11230 2394182..2394436 - 255 WP_003410814.1 antitoxin Antitoxin
JN139_RS11235 2394452..2394709 - 258 WP_003410816.1 hypothetical protein -
JN139_RS11240 2395655..2395951 + 297 WP_003410820.1 PE family protein -
JN139_RS11245 2396007..2396738 + 732 WP_003900467.1 PPE family protein -
JN139_RS11250 2397278..2398024 - 747 WP_003901330.1 proteasome subunit alpha -
JN139_RS11255 2398021..2398896 - 876 WP_003411023.1 proteasome subunit beta -
JN139_RS11260 2398893..2399087 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T189621 WP_003410811.1 NZ_CP069074:c2394175-2393741 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T189621 NZ_CP090890:c2800846-2800451 [Acinetobacter junii]
ATGTACACGGCTAAACGTATTTTTGAGCTGCAATCTAGTCGATTTTCGCTAGGATTGCAGCTGTTTTGTTTTTTGGGTAT
CAATATCCTACTTTATCAATTATTGTCAGCTTTTTTATGGTTAGTGTGCTTGTTGATTATGGGATGGGCGGGCTGGTCGG
CATTAAACAAACCGAAAATAAATCAAATTGAGTATCTCTATGACGATGATTGGTCGATTCGTTTTGATGGAGCCGTGCCT
AATATTGAGCAAGGAAAATTACTCAAAATTGTTGATCATCATTTATATATTGTGCTGTATTTTTCTAATATTGAATCAAA
AACATGTGTAATTTGGTGGGATCAATTGTCTTTAAATCAATGGAAAATGCTGAAATTACTCTCAAAACTTGCATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT189621 WP_003410814.1 NZ_CP069074:c2394436-2394182 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT189621 NZ_CP090890:c2801090-2800833 [Acinetobacter junii]
ATGTCTGATGAAATGACACTGGAAGAGCGCAAGGTGATTTATCGTGCACGTCGTGGGTTAAAAGAAATTGATGTGTACTT
TGACCCTTATGTTAAACAATATTATTTGACTGCAGACCCAACAGAAAAAGCATTATTTGCAGAGTTGGTGGATCAAGAAG
ATCCTGATTTGTTGGATTGGTTTATGGAGGTGGGTGAGCCACCACGTGCAGAGTTAAAAGCGTTTATTTTAAAATTAAAA
AAATATGTACACGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References