Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2218786..2219330 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JN139_RS10380 Protein ID WP_003409896.1
Coordinates 2218786..2219082 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JN139_RS10385 Protein ID WP_003409899.1
Coordinates 2219079..2219330 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS10325 2213819..2214169 - 351 WP_003409871.1 hypothetical protein -
JN139_RS10330 2214180..2215082 - 903 WP_003899097.1 hypothetical protein -
JN139_RS10335 2215103..2215294 - 192 WP_003409876.1 hypothetical protein -
JN139_RS10340 2215295..2215591 - 297 WP_003409877.1 hypothetical protein -
JN139_RS10345 2215831..2216046 + 216 WP_003409878.1 antitoxin -
JN139_RS10350 2216043..2216354 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN139_RS10355 2216328..2216849 - 522 WP_003904745.1 hypothetical protein -
JN139_RS10360 2216824..2217201 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JN139_RS10365 2217243..2217692 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JN139_RS10370 2217689..2218234 + 546 WP_003409891.1 SecB-like chaperone -
JN139_RS10375 2218123..2218737 - 615 WP_003901296.1 hypothetical protein -
JN139_RS10380 2218786..2219082 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN139_RS10385 2219079..2219330 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JN139_RS10390 2219317..2219811 + 495 WP_003899099.1 hypothetical protein -
JN139_RS10395 2219971..2220378 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN139_RS10400 2220382..2220654 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN139_RS10405 2220687..2221907 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JN139_RS10410 2222806..2223603 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T189614 WP_003409896.1 NZ_CP069074:c2219082-2218786 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T189614 NZ_CP090887:c1616370-1616191 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT189614 WP_003409899.1 NZ_CP069074:c2219330-2219079 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT189614 NZ_CP090887:c1616154-1615702 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References