Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2209749..2210452 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag JN139_RS10290 Protein ID WP_003409778.1
Coordinates 2209749..2210078 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag JN139_RS10295 Protein ID WP_003409780.1
Coordinates 2210075..2210452 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS10270 2206132..2207202 + 1071 WP_003899091.1 epoxide hydrolase EphB -
JN139_RS10275 2207199..2207714 + 516 WP_003409718.1 flavin reductase family protein -
JN139_RS10280 2207711..2208772 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
JN139_RS10285 2208769..2209539 + 771 WP_003409775.1 SDR family oxidoreductase -
JN139_RS10290 2209749..2210078 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JN139_RS10295 2210075..2210452 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
JN139_RS10300 2210449..2211039 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
JN139_RS10305 2211094..2212458 + 1365 WP_003903691.1 HNH endonuclease signature motif containing protein -
JN139_RS10310 2212613..2213065 - 453 WP_003899095.1 lipoprotein -
JN139_RS10315 2213129..2213530 + 402 WP_003409869.1 hypothetical protein -
JN139_RS10320 2213523..2213705 - 183 WP_003409870.1 hypothetical protein -
JN139_RS10325 2213819..2214169 - 351 WP_003409871.1 hypothetical protein -
JN139_RS10330 2214180..2215082 - 903 WP_003899097.1 hypothetical protein -
JN139_RS10335 2215103..2215294 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T189612 WP_003409778.1 NZ_CP069074:c2210078-2209749 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

>T189612 NZ_CP090887:1082878-1083636 [Streptococcus pneumoniae]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCAATTTTGCTTGGAGGGCAAAGTGGTGCTGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTCAGGACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
GGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATATGAAGAA
CTATACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGGCAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATTATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT189612 WP_003409780.1 NZ_CP069074:c2210452-2210075 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp

>AT189612 NZ_CP090887:1082402-1082878 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGACTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTTTTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References