Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3790748..3791277 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JN140_RS17875 Protein ID WP_003417760.1
Coordinates 3791020..3791277 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JN140_RS17870 Protein ID WP_003417757.1
Coordinates 3790748..3791023 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS17835 3787321..3788010 - 690 WP_003917774.1 BBE domain-containing protein -
JN140_RS17840 3788197..3788568 - 372 WP_003417739.1 FAD-binding protein -
JN140_RS17845 3788466..3788684 - 219 WP_157132559.1 hypothetical protein -
JN140_RS17850 3788711..3788971 - 261 WP_003417741.1 hypothetical protein -
JN140_RS17855 3789086..3789475 + 390 WP_003417745.1 DUF732 domain-containing protein -
JN140_RS17860 3789489..3789782 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JN140_RS17865 3789779..3790624 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JN140_RS17870 3790748..3791023 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JN140_RS17875 3791020..3791277 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JN140_RS17880 3791319..3792509 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JN140_RS17885 3792626..3792993 + 368 Protein_3532 FHA domain-containing protein -
JN140_RS17890 3792990..3793541 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
JN140_RS17895 3793548..3794129 - 582 WP_003417769.1 ATP/GTP-binding protein -
JN140_RS17900 3794110..3794478 - 369 WP_003417772.1 DUF742 domain-containing protein -
JN140_RS17905 3794456..3794848 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T189578 WP_003417760.1 NZ_CP069073:3791020-3791277 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T189578 NZ_CP090879:1466887-1466994 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGACTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT189578 WP_003417757.1 NZ_CP069073:3790748-3791023 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT189578 NZ_CP090879:c1467071-1467011 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References