Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3721717..3722391 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JN140_RS17660 Protein ID WP_003417282.1
Coordinates 3721717..3722145 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JN140_RS17665 Protein ID WP_003417286.1
Coordinates 3722149..3722391 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS17635 3717539..3717940 - 402 WP_003417264.1 cytidine deaminase -
JN140_RS17640 3718177..3718515 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
JN140_RS17645 3718512..3718946 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JN140_RS17650 3719075..3720847 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JN140_RS17655 3720847..3721638 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JN140_RS17660 3721717..3722145 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JN140_RS17665 3722149..3722391 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
JN140_RS17670 3722513..3723127 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JN140_RS17675 3723124..3723789 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JN140_RS17680 3723790..3724323 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JN140_RS17685 3724320..3724694 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JN140_RS17690 3724791..3725795 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T189577 WP_003417282.1 NZ_CP069073:c3722145-3721717 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T189577 NZ_CP090879:1435490-1435756 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT189577 WP_003417286.1 NZ_CP069073:c3722391-3722149 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT189577 NZ_CP090879:1435233-1435490 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References