189575

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3195980..3196667 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag JN140_RS15285 Protein ID WP_003414624.1
Coordinates 3196224..3196667 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN140_RS15280 Protein ID WP_031647372.1
Coordinates 3195980..3196237 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS15260 3191300..3192154 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JN140_RS15265 3192210..3193373 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN140_RS15270 3193390..3194604 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN140_RS15275 3194612..3195853 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
JN140_RS15280 3195980..3196237 + 258 WP_031647372.1 ribbon-helix-helix domain-containing protein Antitoxin
JN140_RS15285 3196224..3196667 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
JN140_RS15290 3196747..3197409 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
JN140_RS15295 3197505..3197696 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JN140_RS15300 3198028..3199776 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
JN140_RS15305 3199872..3200453 + 582 WP_003414644.1 fasciclin domain-containing protein -
JN140_RS15310 3200553..3200819 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T189575 WP_003414624.1 NZ_CP069073:3196224-3196667 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T189575 NZ_CP090879:c292603-292352 [Staphylococcus aureus]
ATGAATAATCGCGAAAAAATCGAACAGTCCGTTATTAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGGTTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGGA
AATGACTATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8960.17 Da        Isoelectric Point: 10.2193

>AT189575 WP_031647372.1 NZ_CP069073:3195980-3196237 [Mycobacterium tuberculosis]
VRTTIRIDDELYCEVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT189575 NZ_CP090879:c292362-292189 [Staphylococcus aureus]
ATGACTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure

References