Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2865952..2866592 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag JN140_RS13465 Protein ID WP_003412970.1
Coordinates 2865952..2866371 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN140_RS13470 Protein ID WP_031647222.1
Coordinates 2866368..2866592 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS13435 2861537..2862259 - 723 WP_003412957.1 DUF1906 domain-containing protein -
JN140_RS13440 2862776..2863003 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
JN140_RS13445 2863000..2863401 + 402 WP_003412963.1 PIN domain-containing protein -
JN140_RS13450 2863436..2864356 - 921 WP_003412965.1 restriction endonuclease -
JN140_RS13455 2864697..2864903 - 207 WP_229298035.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JN140_RS13460 2865001..2865951 + 951 WP_003911916.1 ERCC4 domain-containing protein -
JN140_RS13465 2865952..2866371 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
JN140_RS13470 2866368..2866592 - 225 WP_031647222.1 antitoxin VapB39 Antitoxin
JN140_RS13475 2866623..2869466 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
JN140_RS13480 2869538..2869939 - 402 WP_003412981.1 hypothetical protein -
JN140_RS13485 2869939..2870409 - 471 WP_003899364.1 transcription antitermination factor NusB -
JN140_RS13490 2870412..2870975 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T189563 WP_003412970.1 NZ_CP069073:c2866371-2865952 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T189563 NZ_CP090876:2527358-2527465 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGTGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8021.99 Da        Isoelectric Point: 4.1116

>AT189563 WP_031647222.1 NZ_CP069073:c2866592-2866368 [Mycobacterium tuberculosis]
MRTTLRIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT189563 NZ_CP090876:c2527542-2527482 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCCGTAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure

References