Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 2413847..2414376 | Replicon | chromosome |
Accession | NZ_CP069073 | ||
Organism | Mycobacterium tuberculosis strain N0054 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TMR4 |
Locus tag | JN140_RS11355 | Protein ID | WP_003411124.1 |
Coordinates | 2413847..2414164 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P9WJ74 |
Locus tag | JN140_RS11360 | Protein ID | WP_003411127.1 |
Coordinates | 2414161..2414376 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN140_RS11325 | 2408984..2410060 | + | 1077 | WP_244750255.1 | hypothetical protein | - |
JN140_RS11330 | 2410057..2410338 | + | 282 | WP_003411112.1 | DUF5703 family protein | - |
JN140_RS11335 | 2410374..2411447 | + | 1074 | WP_003411116.1 | quinone-dependent dihydroorotate dehydrogenase | - |
JN140_RS11340 | 2411452..2411982 | - | 531 | WP_003411119.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
JN140_RS11345 | 2412030..2413376 | - | 1347 | WP_003411121.1 | M20/M25/M40 family metallo-hydrolase | - |
JN140_RS11355 | 2413847..2414164 | - | 318 | WP_003411124.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JN140_RS11360 | 2414161..2414376 | - | 216 | WP_003411127.1 | antitoxin ParD2 | Antitoxin |
JN140_RS11365 | 2414631..2415689 | + | 1059 | WP_003411129.1 | phosphoribosyltransferase family protein | - |
JN140_RS11370 | 2415819..2416175 | - | 357 | WP_003411130.1 | hypothetical protein | - |
JN140_RS11375 | 2416270..2417052 | - | 783 | WP_031647332.1 | cell wall synthesis protein Wag31 | - |
JN140_RS11380 | 2417320..2417610 | - | 291 | WP_003900476.1 | YggT family protein | - |
JN140_RS11385 | 2417772..2418428 | - | 657 | WP_003411133.1 | cell division protein SepF | - |
JN140_RS11390 | 2418494..2419270 | - | 777 | WP_003411137.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12312.88 Da Isoelectric Point: 6.4831
>T189561 WP_003411124.1 NZ_CP069073:c2414164-2413847 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
Download Length: 318 bp
>T189561 NZ_CP090876:1439410-1439598 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7880.70 Da Isoelectric Point: 4.4055
>AT189561 WP_003411127.1 NZ_CP069073:c2414376-2414161 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
Download Length: 216 bp
>AT189561 NZ_CP090876:1439121-1439381 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACAACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATTACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCGATT
TTTTATAGGTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACAACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATTACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCGATT
TTTTATAGGTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FAJ4 |