Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2413847..2414376 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN140_RS11355 Protein ID WP_003411124.1
Coordinates 2413847..2414164 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN140_RS11360 Protein ID WP_003411127.1
Coordinates 2414161..2414376 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS11325 2408984..2410060 + 1077 WP_244750255.1 hypothetical protein -
JN140_RS11330 2410057..2410338 + 282 WP_003411112.1 DUF5703 family protein -
JN140_RS11335 2410374..2411447 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN140_RS11340 2411452..2411982 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN140_RS11345 2412030..2413376 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN140_RS11355 2413847..2414164 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN140_RS11360 2414161..2414376 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN140_RS11365 2414631..2415689 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN140_RS11370 2415819..2416175 - 357 WP_003411130.1 hypothetical protein -
JN140_RS11375 2416270..2417052 - 783 WP_031647332.1 cell wall synthesis protein Wag31 -
JN140_RS11380 2417320..2417610 - 291 WP_003900476.1 YggT family protein -
JN140_RS11385 2417772..2418428 - 657 WP_003411133.1 cell division protein SepF -
JN140_RS11390 2418494..2419270 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189561 WP_003411124.1 NZ_CP069073:c2414164-2413847 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189561 NZ_CP090876:1439410-1439598 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189561 WP_003411127.1 NZ_CP069073:c2414376-2414161 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189561 NZ_CP090876:1439121-1439381 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACAACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATTACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCGATT
TTTTATAGGTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References