Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2375743..2376438 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN140_RS11145 Protein ID WP_003410811.1
Coordinates 2375743..2376177 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN140_RS11150 Protein ID WP_003410814.1
Coordinates 2376184..2376438 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS11135 2371897..2374938 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JN140_RS11140 2374931..2375764 + 834 WP_244750253.1 SWIM zinc finger family protein -
JN140_RS11145 2375743..2376177 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN140_RS11150 2376184..2376438 - 255 WP_003410814.1 antitoxin Antitoxin
JN140_RS11155 2376454..2376711 - 258 WP_003410816.1 hypothetical protein -
JN140_RS11165 2379015..2379311 + 297 WP_003410820.1 PE family protein -
JN140_RS11170 2379367..2380098 + 732 WP_003900467.1 PPE family protein -
JN140_RS11175 2380638..2381384 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T189560 WP_003410811.1 NZ_CP069073:c2376177-2375743 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T189560 NZ_CP090876:c456809-456714 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT189560 WP_003410814.1 NZ_CP069073:c2376438-2376184 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT189560 NZ_CP090876:456629-456686 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References