Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203170..2203714 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JN140_RS10330 Protein ID WP_003409896.1
Coordinates 2203170..2203466 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JN140_RS10335 Protein ID WP_003409899.1
Coordinates 2203463..2203714 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS10275 2198203..2198553 - 351 WP_003409871.1 hypothetical protein -
JN140_RS10280 2198564..2199466 - 903 WP_003899097.1 hypothetical protein -
JN140_RS10285 2199487..2199678 - 192 WP_003409876.1 hypothetical protein -
JN140_RS10290 2199679..2199975 - 297 WP_003409877.1 hypothetical protein -
JN140_RS10295 2200215..2200430 + 216 WP_003409878.1 antitoxin -
JN140_RS10300 2200427..2200738 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN140_RS10305 2200712..2201233 - 522 WP_003904745.1 hypothetical protein -
JN140_RS10310 2201208..2201585 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JN140_RS10315 2201627..2202076 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JN140_RS10320 2202073..2202618 + 546 WP_003409891.1 SecB-like chaperone -
JN140_RS10325 2202507..2203121 - 615 WP_003901296.1 hypothetical protein -
JN140_RS10330 2203170..2203466 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN140_RS10335 2203463..2203714 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JN140_RS10340 2203701..2204195 + 495 WP_003899099.1 hypothetical protein -
JN140_RS10345 2204355..2204762 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN140_RS10350 2204766..2205038 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN140_RS10355 2205071..2206291 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JN140_RS10360 2207190..2207987 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T189553 WP_003409896.1 NZ_CP069073:c2203466-2203170 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T189553 NZ_CP090873:1690838-1690990 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT189553 WP_003409899.1 NZ_CP069073:c2203714-2203463 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT189553 NZ_CP090873:1690214-1690813 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References