Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1395944..1396503 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag JN140_RS06675 Protein ID WP_003898789.1
Coordinates 1395944..1396237 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag JN140_RS06680 Protein ID WP_003406322.1
Coordinates 1396234..1396503 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS06650 1391539..1391799 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
JN140_RS06655 1391796..1392227 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
JN140_RS06660 1392250..1393936 - 1687 Protein_1314 PE family protein -
JN140_RS06665 1394116..1394976 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
JN140_RS06670 1395057..1395887 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
JN140_RS06675 1395944..1396237 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JN140_RS06680 1396234..1396503 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN140_RS06685 1396616..1400311 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
JN140_RS06690 1400453..1401241 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T189544 WP_003898789.1 NZ_CP069073:c1396237-1395944 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T189544 NZ_CP090870:c2099886-2099698 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT189544 WP_003406322.1 NZ_CP069073:c1396503-1396234 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT189544 NZ_CP090870:c2100175-2099915 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References