Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1391539..1392227 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag JN140_RS06655 Protein ID WP_003406304.1
Coordinates 1391796..1392227 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag JN140_RS06650 Protein ID WP_003406302.1
Coordinates 1391539..1391799 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS06630 1387116..1387940 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
JN140_RS06635 1387945..1389126 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
JN140_RS06640 1389203..1390303 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
JN140_RS06645 1390474..1391463 + 990 WP_003406301.1 malate dehydrogenase -
JN140_RS06650 1391539..1391799 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
JN140_RS06655 1391796..1392227 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
JN140_RS06660 1392250..1393936 - 1687 Protein_1314 PE family protein -
JN140_RS06665 1394116..1394976 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
JN140_RS06670 1395057..1395887 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
JN140_RS06675 1395944..1396237 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
JN140_RS06680 1396234..1396503 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T189543 WP_003406304.1 NZ_CP069073:1391796-1392227 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T189543 NZ_CP090870:c958047-957781 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT189543 WP_003406302.1 NZ_CP069073:1391539-1391799 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT189543 NZ_CP090870:c958304-958047 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References