Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 760493..761285 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN140_RS03530 Protein ID WP_003403386.1
Coordinates 760848..761285 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag JN140_RS03525 Protein ID WP_003403381.1
Coordinates 760493..760738 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS03495 755513..757018 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JN140_RS03500 757099..758109 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN140_RS03505 758497..758880 - 384 WP_015629650.1 hypothetical protein -
JN140_RS03510 758975..759130 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JN140_RS03515 759206..759922 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN140_RS03520 760198..760506 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN140_RS03525 760493..760738 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
JN140_RS03530 760848..761285 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JN140_RS03535 761282..761536 - 255 WP_003911263.1 antitoxin VapB7 -
JN140_RS03540 761650..764013 + 2364 WP_003403397.1 arylsulfatase AtsD -
JN140_RS03545 764076..764402 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN140_RS03550 764314..764652 + 339 WP_003403405.1 PIN domain-containing protein -
JN140_RS03555 764649..764822 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T189536 WP_003403386.1 NZ_CP069073:c761285-760848 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T189536 NZ_CP090870:c454878-454702 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT189536 WP_003403381.1 NZ_CP069073:c760738-760493 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT189536 NZ_CP090870:454571-454712 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References