Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 758497..759130 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN140_RS03505 Protein ID WP_015629650.1
Coordinates 758497..758880 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JN140_RS03510 Protein ID WP_003403368.1
Coordinates 758975..759130 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS03480 753789..754325 + 537 WP_003403341.1 50S ribosomal protein L10 -
JN140_RS03485 754362..754754 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JN140_RS03490 754747..755442 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JN140_RS03495 755513..757018 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JN140_RS03500 757099..758109 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN140_RS03505 758497..758880 - 384 WP_015629650.1 hypothetical protein Toxin
JN140_RS03510 758975..759130 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN140_RS03515 759206..759922 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN140_RS03520 760198..760506 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN140_RS03525 760493..760738 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN140_RS03530 760848..761285 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JN140_RS03535 761282..761536 - 255 WP_003911263.1 antitoxin VapB7 -
JN140_RS03540 761650..764013 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13886.68 Da        Isoelectric Point: 6.0803

>T189534 WP_015629650.1 NZ_CP069073:c758880-758497 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRLIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T189534 NZ_CP090870:300233-300328 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT189534 WP_003403368.1 NZ_CP069073:c759130-758975 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT189534 NZ_CP090870:c300413-300356 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References