Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 721390..722039 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JN140_RS03320 Protein ID WP_003403236.1
Coordinates 721644..722039 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JN140_RS03315 Protein ID WP_003403235.1
Coordinates 721390..721644 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS03285 716549..716950 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 -
JN140_RS03290 717079..717162 + 84 Protein_652 galactose-1-phosphate uridylyltransferase -
JN140_RS03295 717181..718262 + 1082 Protein_653 galactose-1-phosphate uridylyltransferase -
JN140_RS03300 718259..719350 + 1092 WP_003900977.1 galactokinase -
JN140_RS03305 719680..720246 + 567 Protein_655 hypothetical protein -
JN140_RS03310 720350..721297 + 948 WP_003403232.1 DUF732 domain-containing protein -
JN140_RS03315 721390..721644 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JN140_RS03320 721644..722039 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JN140_RS03325 722133..722873 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN140_RS03330 723005..723265 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN140_RS03335 723262..723669 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JN140_RS03340 723741..724892 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
JN140_RS03345 724985..726712 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T189532 WP_003403236.1 NZ_CP069073:721644-722039 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T189532 NZ_CP090838:c3341108-3340419 [Bacillus amyloliquefaciens]
TTGATCAAATGTACTTGTCGGATTGAGTCATTTTGCAACCATCTTCATCAGTTGATACTTGAAATAAATCAGTTGCATAG
TGATTTTTCAACCAACTTCAGCTTAAAACAAGATGTAAAGCATGTTCATTTAAAAAAAACTCAAATAAGACACGTAACAG
AAGTTACAGAAAAAAGGAACATTTTCTCAATCGACAATGATTTTTTTATTTTGCTCCAACATTACGCAGATAAACTAGAA
GATATTGTCATTTATAATGACTTGGAATATCTGTACAGTGAATTTGATTTGCGGCTTAGAGTAAAACAACCAGATTCCAT
TGTCAATAAGCTTAAATATTATCGTGTGGGAAAAAAAGAAAGCGGGCAAATAGCTTTAAGAAAGTGCCTGAATGATTTGT
TGGGTATTCGAATAACAATTGACTCTTTTGACCATAATAATAAATGCTTTCAGGACATGTGTGAGTTGTTGAAAAAACAA
TACAAAATAAATTGTATGGATTCTTCCAAAGGCGACTACAAAGCATTTCATTTTTATTTTTATGGTGAGAGTACTTTTTT
CTTCCCATGGGAGCTTCAAATCTGGAGAACAGACGATAAAGAAGCGAATAATCGTTCGCATCAACTTCATAAACAAGCTT
ATAAAGGTTGGGCGTCGATTTATAAGAATTCCACAGAAGTGGAGAAGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT189532 WP_003403235.1 NZ_CP069073:721390-721644 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT189532 NZ_CP090838:c3340407-3339658 [Bacillus amyloliquefaciens]
ATGGCATTTCATTTTATCGCGATCATTAGTGATTTTTCTGGTGGTAGAAGAATGGGCTGGCACTATTCAAGTGAAGAAAG
ATTGGATAAAAACTACATTTCCGACTTCTTTGAAAGAGTTAAAGAAAAATGTGGCATGGTTCAATTCGGAATTCACAAAC
TATCAACCGATTCAACTAGTTGGAAATCTGTAACCGAGAAAGATTCCTTTTTCGATGATGTTTATGTTACAGAAGATATT
TCAACCTTTATAGATGTGATCTCAAAAGACAAAGAACTAACCGCATATGATGTGGCGAAATTTGTCCTGTCTTTTAAACC
AGCGTCTCACTTAAAATTACAAAAACTACTTTATTATATCTATGCGGAGTTTTTGTTGAAAACAGGGGAAAAGCTATTCA
AAGAACCTATAGTAGCGTTTAAATATGGGCCAGTTATTGAGAGCATTTTCTATAAATACAAAACTCATGGCAAAAGTGAA
ATAGATTATGAAGAAGATGCTTCTATAAAGCTTCGTACAGACGATGTAGTAATAACACCTTCTTTTATGAAGATTTTATC
TTCTGAGTATGGAATTGAAGCTCTTGGATGTATTATAGAAGTTCTTGTTAAGTACGGACGATATAGTGCATTTGGTTTAG
TTGAAAAAACTCATCAAGATGGTGGGCCGTGGCATAGAGTATACAAACCAGGTCAAAATTGTGTAATAACTGATGAACTT
ATTACTCAATATCACCAACATGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References