Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 716325..716950 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN140_RS03285 Protein ID WP_003403218.1
Coordinates 716549..716950 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN140_RS03280 Protein ID WP_003403213.1
Coordinates 716325..716552 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS03255 711504..711725 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN140_RS03260 711867..712472 + 606 WP_003898526.1 hypothetical protein -
JN140_RS03265 712491..715058 - 2568 WP_031647101.1 SEC-C metal-binding domain-containing protein -
JN140_RS03270 715142..715891 + 750 WP_003898528.1 hypothetical protein -
JN140_RS03275 715888..716130 + 243 WP_003403210.1 hypothetical protein -
JN140_RS03280 716325..716552 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN140_RS03285 716549..716950 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN140_RS03290 717079..717162 + 84 Protein_652 galactose-1-phosphate uridylyltransferase -
JN140_RS03295 717181..718262 + 1082 Protein_653 galactose-1-phosphate uridylyltransferase -
JN140_RS03300 718259..719350 + 1092 WP_003900977.1 galactokinase -
JN140_RS03305 719680..720246 + 567 Protein_655 hypothetical protein -
JN140_RS03310 720350..721297 + 948 WP_003403232.1 DUF732 domain-containing protein -
JN140_RS03315 721390..721644 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T189531 WP_003403218.1 NZ_CP069073:716549-716950 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T189531 NZ_CP090838:c3299357-3298668 [Bacillus amyloliquefaciens]
TTGATCAAATGTACTTGTCGGATTGAGTCATTTTGCAACCATCTTCATCAGTTGATACTTGAAATAAATCAGTTGCATAG
TGATTTTTCAACCAACTTCAGCTTAAAACAAGATGTAAAGCATGTTCATTTAAAAAAAACTCAAATAAGACACGTAACAG
AAGTTACAGAAAAAAGGAACATTTTCTCAATCGACAATGATTTTTTTATTTTGCTCCAACATTACGCAGATAAACTAGAA
GATATTGTCATTTATAATGACTTGGAATATCTGTACAGTGAATTTGATTTGCGGCTTAGAGTAAAACAACCAGATTCCAT
TGTCAATAAGCTTAAATATTATCGTGTGGGAAAAAAAGAAAGCGGGCAAATAGCTTTAAGAAAGTGCCTGAATGATTTGT
TGGGTATTCGAATAACAATTGACTCTTTTGACCATAATAATAAATGCTTTCAGGACATGTGTGAGTTGTTGAAAAAACAA
TACAAAATAAATTGTATGGATTCTTCCAAAGGCGACTACAAAGCATTTCATTTTTATTTTTATGGTGAGAGTACTTTTTT
CTTCCCATGGGAGCTTCAAATCTGGAGAACAGACGATAAAGAAGCGAATAATCGTTCGCATCAACTTCATAAACAAGCTT
ATAAAGGTTGGGCGTCGATTTATAAGAATTCCACAGAAGTGGAGAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT189531 WP_003403213.1 NZ_CP069073:716325-716552 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT189531 NZ_CP090838:c3298656-3297907 [Bacillus amyloliquefaciens]
ATGGCATTTCATTTTATCGCGATCATTAGTGATTTTTCTGGTGGTAGAAGAATGGGCTGGCACTATTCAAGTGAAGAAAG
ATTGGATAAAAACTACATTTCCGACTTCTTTGAAAGAGTTAAAGAAAAATGTGGCATGGTTCAATTCGGAATTCACAAAC
TATCAACCGATTCAACTAGTTGGAAATCTGTAACCGAGAAAGATTCCTTTTTCGATGATGTTTATGTTACAGAAGATATT
TCAACCTTTATAGATGTGATCTCAAAAGACAAAGAACTAACCGCATATGATGTGGCGAAATTTGTCCTGTCTTTTAAACC
AGCGTCTCACTTAAAATTACAAAAACTACTTTATTATATCTATGCGGAGTTTTTGTTGAAAACAGGGGAAAAGCTATTCA
AAGAACCTATAGTAGCGTTTAAATATGGGCCAGTTATTGAGAGCATTTTCTATAAATACAAAACTCATGGCAAAAGTGAA
ATAGATTATGAAGAAGATGCTTCTATAAAGCTTCGTACAGACGATGTAGTAATAACACCTTCTTTTATGAAGATTTTATC
TTCTGAGTATGGAATTGAAGCTCTTGGATGTATTATAGAAGTTCTTGTTAAGTACGGACGATATAGTGCATTTGGTTTAG
TTGAAAAAACTCATCAAGATGGTGGGCCGTGGCATAGAGTATACAAACCAGGTCAAAATTGTGTAATAACTGATGAACTT
ATTACTCAATATCACCAACATGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References