Detailed information of TA system TA189522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 367537..368063
• Replicon: chromosome
• Accession: NZ_CP069073
• Organism: Mycobacterium tuberculosis strain N0054

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: JN140_RS01600
• Protein ID: WP_015629470.1
• Coordinates: 367761..368063 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: JN140_RS01595
• Protein ID: WP_003401555.1
• Coordinates: 367537..367764 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN140_RS01580	363230..364033	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
JN140_RS01585	364043..365440	-	1398	WP_003401544.1	sulfatase	-
JN140_RS01590	365619..367394	+	1776	WP_010886074.1	PE family protein	-
JN140_RS01595	367537..367764	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
JN140_RS01600	367761..368063	+	303	WP_015629470.1	toxin-antitoxin system toxin	Toxin
JN140_RS01605	368111..368332	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
JN140_RS01610	368329..368754	+	426	WP_003401566.1	PIN domain nuclease	-
JN140_RS01615	368890..369522	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
JN140_RS01620	369519..370427	+	909	WP_003900117.1	protochlorophyllide reductase	-
JN140_RS01625	370435..371025	-	591	WP_229298012.1	hypothetical protein	-
JN140_RS01630	371018..371068	-	51	Protein_322	hypothetical protein	-
JN140_RS01635	371266..372471	-	1206	Protein_323	PPE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10472.19 Da
• Isoelectric Point: 4.9609

>T189522 WP_015629470.1 NZ_CP069073:367761-368063 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRATDTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T189522 NZ_CP090834:1462829-1463239 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT189522 WP_003401555.1 NZ_CP069073:367537-367764 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT189522 NZ_CP090834:1462582-1462848 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1