189514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3176621..3177169 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JN141_RS15150 Protein ID WP_003414602.1
Coordinates 3176906..3177169 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JN141_RS15145 Protein ID WP_003414599.1
Coordinates 3176621..3176902 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS15120 3172244..3173101 - 858 WP_003899513.1 type I methionyl aminopeptidase -
JN141_RS15125 3173143..3173727 - 585 WP_003899514.1 DUF1707 domain-containing protein -
JN141_RS15130 3173831..3174079 + 249 WP_003913411.1 antitoxin VapB23 -
JN141_RS15135 3174076..3174456 + 381 WP_019256956.1 type II toxin-antitoxin system VapC family toxin -
JN141_RS15140 3174538..3176349 - 1812 WP_003414596.1 penicillin-binding protein -
JN141_RS15145 3176621..3176902 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JN141_RS15150 3176906..3177169 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN141_RS15155 3177542..3178396 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JN141_RS15160 3178452..3179615 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN141_RS15165 3179632..3180846 - 1215 WP_003899518.1 zinc metalloprotease Rip -
JN141_RS15170 3180854..3182095 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T189514 WP_003414602.1 NZ_CP069072:3176906-3177169 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T189514 NZ_CP090796:c2718434-2718331 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT189514 WP_003414599.1 NZ_CP069072:3176621-3176902 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT189514 NZ_CP090796:2718328-2718527 [Enterobacter hormaechei]
GATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGTCT
GAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWP8

References