Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402681..2403210 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN141_RS11265 Protein ID WP_003411124.1
Coordinates 2402681..2402998 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN141_RS11270 Protein ID WP_003411127.1
Coordinates 2402995..2403210 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS11235 2397818..2398894 + 1077 WP_003411110.1 hypothetical protein -
JN141_RS11240 2398891..2399172 + 282 WP_003411112.1 DUF5703 family protein -
JN141_RS11245 2399208..2400281 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN141_RS11250 2400286..2400816 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN141_RS11255 2400864..2402210 - 1347 WP_244747861.1 M20/M25/M40 family metallo-hydrolase -
JN141_RS11265 2402681..2402998 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN141_RS11270 2402995..2403210 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN141_RS11275 2403465..2404523 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN141_RS11280 2404653..2405009 - 357 WP_003411130.1 hypothetical protein -
JN141_RS11285 2405104..2405886 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN141_RS11290 2406154..2406444 - 291 WP_003900476.1 YggT family protein -
JN141_RS11295 2406606..2407262 - 657 WP_003411133.1 cell division protein SepF -
JN141_RS11300 2407328..2408104 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189501 WP_003411124.1 NZ_CP069072:c2402998-2402681 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189501 NZ_CP090792:c2867520-2867417 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189501 WP_003411127.1 NZ_CP069072:c2403210-2402995 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189501 NZ_CP090792:2867412-2867613 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References