Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2226889..2227787 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JN141_RS10440 Protein ID WP_003410001.1
Coordinates 2226889..2227449 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JN141_RS10445 Protein ID WP_003410003.1
Coordinates 2227446..2227787 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS10410 2222058..2222711 - 654 WP_003409976.1 cutinase Cfp21 -
JN141_RS10415 2222826..2223056 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN141_RS10420 2223141..2224052 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN141_RS10425 2224161..2224760 + 600 WP_003409989.1 L-lysine exporter -
JN141_RS10430 2225176..2225604 + 429 WP_003409992.1 cellulose-binding protein -
JN141_RS10435 2225830..2226369 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JN141_RS10440 2226889..2227449 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JN141_RS10445 2227446..2227787 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JN141_RS10450 2227873..2228130 + 258 WP_003410006.1 hypothetical protein -
JN141_RS10455 2228031..2228366 - 336 WP_003410009.1 dehydrogenase -
JN141_RS10460 2228455..2228799 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JN141_RS10465 2228793..2229041 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JN141_RS10470 2229141..2231456 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN141_RS10475 2231453..2231725 - 273 WP_003410017.1 DUF1490 family protein -
JN141_RS10480 2231778..2232134 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T189495 WP_003410001.1 NZ_CP069072:c2227449-2226889 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T189495 NZ_CP090790:368109-368393 [Bifidobacterium longum]
ATGAGCACCGAAATCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCACTCGGCAACGTCGCCAAGGCTCGAGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAAAGCCTCAGCAAGGACGGAAACCCCAGCTTCCAGACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT189495 WP_003410003.1 NZ_CP069072:c2227787-2227446 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT189495 NZ_CP090790:367807-368112 [Bifidobacterium longum]
ATGGAAATCAAGCAAACCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGAACCGCGAGGCGAAAGCCGCCATCCAAGC
CCGGCTCGACGCCTGCAAGCTCGCCGGCAGGCCGTTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACATCGGAGCCGGATACCGCGTCTACTTCACCACGCGCGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAAACAAGCCCACGCCATACTCGACGACTACAAGGAGCAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References