Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2219563..2220251 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN141_RS10395 Protein ID WP_003409958.1
Coordinates 2219563..2219982 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN141_RS10400 Protein ID WP_003409968.1
Coordinates 2219991..2220251 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS10375 2215055..2215906 + 852 WP_031650906.1 class I SAM-dependent methyltransferase -
JN141_RS10380 2215866..2217314 - 1449 WP_031650907.1 APC family permease -
JN141_RS10385 2217493..2218179 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JN141_RS10390 2218370..2219338 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN141_RS10395 2219563..2219982 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN141_RS10400 2219991..2220251 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN141_RS10405 2220394..2222070 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN141_RS10410 2222058..2222711 - 654 WP_003409976.1 cutinase Cfp21 -
JN141_RS10415 2222826..2223056 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN141_RS10420 2223141..2224052 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN141_RS10425 2224161..2224760 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189494 WP_003409958.1 NZ_CP069072:c2219982-2219563 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189494 NZ_CP090790:367807-368112 [Bifidobacterium longum]
ATGGAAATCAAGCAAACCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGAACCGCGAGGCGAAAGCCGCCATCCAAGC
CCGGCTCGACGCCTGCAAGCTCGCCGGCAGGCCGTTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACATCGGAGCCGGATACCGCGTCTACTTCACCACGCGCGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAAACAAGCCCACGCCATACTCGACGACTACAAGGAGCAGCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189494 WP_003409968.1 NZ_CP069072:c2220251-2219991 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189494 NZ_CP090790:368109-368393 [Bifidobacterium longum]
ATGAGCACCGAAATCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCACTCGGCAACGTCGCCAAGGCTCGAGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAAAGCCTCAGCAAGGACGGAAACCCCAGCTTCCAGACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References