Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2197827..2198371 | Replicon | chromosome |
| Accession | NZ_CP069072 | ||
| Organism | Mycobacterium tuberculosis strain N1216 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | JN141_RS10275 | Protein ID | WP_003409896.1 |
| Coordinates | 2197827..2198123 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | JN141_RS10280 | Protein ID | WP_003409899.1 |
| Coordinates | 2198120..2198371 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN141_RS10220 | 2192860..2193210 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| JN141_RS10225 | 2193221..2194123 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| JN141_RS10230 | 2194144..2194335 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN141_RS10235 | 2194336..2194632 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN141_RS10240 | 2194872..2195087 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN141_RS10245 | 2195084..2195395 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN141_RS10250 | 2195369..2195890 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN141_RS10255 | 2195865..2196242 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| JN141_RS10260 | 2196284..2196733 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| JN141_RS10265 | 2196730..2197275 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN141_RS10270 | 2197164..2197778 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN141_RS10275 | 2197827..2198123 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JN141_RS10280 | 2198120..2198371 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JN141_RS10285 | 2198358..2198852 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN141_RS10290 | 2199012..2199419 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN141_RS10295 | 2199423..2199695 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN141_RS10300 | 2199728..2200948 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| JN141_RS10305 | 2201847..2202644 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T189493 WP_003409896.1 NZ_CP069072:c2198123-2197827 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T189493 NZ_CP090790:220308-220631 [Bifidobacterium longum]
ATGAAACGAGGTGAGATTCGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCTGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGCT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA
ATGAAACGAGGTGAGATTCGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCTGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGCT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT189493 WP_003409899.1 NZ_CP069072:c2198371-2198120 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT189493 NZ_CP090790:220076-220321 [Bifidobacterium longum]
ATGAGCATACAGATTGCCACGCGAGTTAGTGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGCACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA
ATGAGCATACAGATTGCCACGCGAGTTAGTGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGCACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |