Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2197827..2198371 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JN141_RS10275 Protein ID WP_003409896.1
Coordinates 2197827..2198123 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JN141_RS10280 Protein ID WP_003409899.1
Coordinates 2198120..2198371 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS10220 2192860..2193210 - 351 WP_003899096.1 hypothetical protein -
JN141_RS10225 2193221..2194123 - 903 WP_003899097.1 hypothetical protein -
JN141_RS10230 2194144..2194335 - 192 WP_003409876.1 hypothetical protein -
JN141_RS10235 2194336..2194632 - 297 WP_003409877.1 hypothetical protein -
JN141_RS10240 2194872..2195087 + 216 WP_003409878.1 antitoxin -
JN141_RS10245 2195084..2195395 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN141_RS10250 2195369..2195890 - 522 WP_003904745.1 hypothetical protein -
JN141_RS10255 2195865..2196242 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JN141_RS10260 2196284..2196733 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JN141_RS10265 2196730..2197275 + 546 WP_003409891.1 SecB-like chaperone -
JN141_RS10270 2197164..2197778 - 615 WP_003901296.1 hypothetical protein -
JN141_RS10275 2197827..2198123 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN141_RS10280 2198120..2198371 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JN141_RS10285 2198358..2198852 + 495 WP_003899099.1 hypothetical protein -
JN141_RS10290 2199012..2199419 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN141_RS10295 2199423..2199695 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN141_RS10300 2199728..2200948 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JN141_RS10305 2201847..2202644 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T189493 WP_003409896.1 NZ_CP069072:c2198123-2197827 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T189493 NZ_CP090790:220308-220631 [Bifidobacterium longum]
ATGAAACGAGGTGAGATTCGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCTGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGCT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT189493 WP_003409899.1 NZ_CP069072:c2198371-2198120 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT189493 NZ_CP090790:220076-220321 [Bifidobacterium longum]
ATGAGCATACAGATTGCCACGCGAGTTAGTGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGCACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References