Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 756177..756810 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JN141_RS03485 Protein ID WP_003403365.1
Coordinates 756177..756560 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JN141_RS03490 Protein ID WP_003403368.1
Coordinates 756655..756810 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS03460 751469..752005 + 537 WP_003403341.1 50S ribosomal protein L10 -
JN141_RS03465 752042..752434 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JN141_RS03470 752427..753122 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JN141_RS03475 753193..754698 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JN141_RS03480 754779..755789 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN141_RS03485 756177..756560 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
JN141_RS03490 756655..756810 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN141_RS03495 756886..757602 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN141_RS03500 757878..758186 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN141_RS03505 758173..758418 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN141_RS03510 758528..758965 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JN141_RS03515 758962..759216 - 255 WP_003911263.1 antitoxin VapB7 -
JN141_RS03520 759330..761692 + 2363 Protein_693 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T189473 WP_003403365.1 NZ_CP069072:c756560-756177 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T189473 NZ_CP090779:77380-77781 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGCTATGCACCAATC
CTGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGTTGCGGCTGCGCAGGCA
TACGGCCCCATTCGAGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTGGAGAACTGGCTGATCGGCT
AG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT189473 WP_003403368.1 NZ_CP069072:c756810-756655 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT189473 NZ_CP090779:77144-77380 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTTGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References