Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 719070..719719 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JN141_RS03300 Protein ID WP_003403236.1
Coordinates 719324..719719 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JN141_RS03295 Protein ID WP_003403235.1
Coordinates 719070..719324 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS03270 714196..714279 + 84 Protein_646 galactose-1-phosphate uridylyltransferase -
JN141_RS03275 714298..715379 + 1082 Protein_647 galactose-1-phosphate uridylyltransferase -
JN141_RS03280 715376..716467 + 1092 WP_003906403.1 galactokinase -
JN141_RS03285 716862..717926 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
JN141_RS03290 718030..718977 + 948 WP_003403232.1 DUF732 domain-containing protein -
JN141_RS03295 719070..719324 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JN141_RS03300 719324..719719 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JN141_RS03305 719813..720553 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN141_RS03310 720685..720945 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN141_RS03315 720942..721349 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JN141_RS03320 721421..722572 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
JN141_RS03325 722665..724392 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T189471 WP_003403236.1 NZ_CP069072:719324-719719 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T189471 NZ_CP090778:1953531-1953848 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT189471 WP_003403235.1 NZ_CP069072:719070-719324 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT189471 NZ_CP090778:1953852-1954151 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
TTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References